A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice
Production of an amyloid protein by bacteria within the gut microbiome can influence the pathophysiology of a mouse model of synucleinopathy.
So proud of this paper and all the hard work that went into this story. Bacterial curli fibers produced in the gut can accelerate alpha-syn aggregation in the brains of mice
Potential role of the gut Microbiome in Parkinson's disease through promotion of alpha-synuclein accumulation
Interesting new work by Timothy Sampson et al, Mazmanian lab
: Curli produced by gut bacteria function in a prion-like manner to exacerbate alpha-synuclein aggregation and motor impairments in a mouse model of #Parkinson's disease