Our new paper on how phenotyping affects #GWAS on Major Depressive Disorder is now published on ! Ken Kendler (1/n)
Minimal phenotyping yields genome-wide association signals of low specificity for major depression (Cai et al.)
The relationship between #genetics & #depression is extremely complex. In a new paper, our alumna & collaborators outline why genetic studies on minimal phenotyping definitions of depression yield unclear conclusions.
Above approach might give more hits and more variance in polygenic prediction. But may not be useful to understand the underlying genetic architecture. Here is a fantastic demonstration how heterogeneity pollutes the GWAS signals for MDD
Maybe we don’t learn much because of the poor phenotyping of depression, as was recently shown by and
Indeed. A very nice paper from & show depression doesn’t fit that bill. We see disagreement for migraine & others. Not clear which ones a priori don’t generalize
"Minimal phenotyping yields genome-wide association signals of low specificity for major depression" cc