There have been claims that #COVID19 has acquired mutations leading to more transmissible strains. We formally tested whether this was the case using 15,000 #SARSCoV2 genomes from all over the world: ... and the answer is no, not at all! (1/5)
No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2 #bioRxiv
Interestingly, the majority of recurrent mutations having emerged in #SARSCoV2 to date are not due to mistakes made by the virus during replication. Instead they were caused by the RNA editing machinery, which is part of our immune system. (4/5)
It was a great honour and privilege to do this work in collaboration with a fantastic team of wonderfully talented scientists. Thank you , Damien Richard, , , . (5/5)
A recent preprint () claims that existing SARS-CoV-2 mutations do not increase transmissibility, and that there is evidence for many recurrent mutations being deleterious. I fear the test used is biased, invalidating the conclusions. Here is why 1/7
No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2 Lucy van Dorp , Damien Richard, Cedric CS Tan , Liam P. Shaw , Mislav Acman , Francois Balloux
No single mutation having emerged recurrently to this day is significantly associated with increased transmission of #SARSCoV2. Instead, all those mutations are neutral or deleterious to the virus' transmission, some significantly so. (3/5)
No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2 #biorxiv_genomic
A wonderful & truly collaborative effort with Damien Richard . ➡️ #openscience #genomics #COVID #WomenInSTEM
Our latest tests whether any #mutations recurrently acquired to date impact the #transmission of #SARSCoV2, the virus responsible for #Covid_19. ➡️ #SpoilerAlert we don't. 👇