Proud to announce our new manuscript from the & groups . We did a deep dive into the relationship between rare variant burden and reproductive success with the amazing data from ! Tweet summary πŸ‘‡
Fascinating & careful empirical exploration of genetic evidence that selection, as proposed by Darwin, is shaping the gene pool of contemporary human populations partly through mate choice. Pre-print
How are damaging genetic variants selected out of the gene pool? New research suggests that sexual selection plays a big role – in other words, that people with damaging variants, men in particular, are less likely to find mates and have kids.
What's going on with those extremely loss-of-function depleted genes that have no disease association? Powerhouse explored how the burden of disrupting LoF-depleted genes is associated with reduced reproductive success. Now on #bioRxiv
Sex-biased reduction in reproductive success drives selective constraint on human genes - a really important paper showing effects on male reproductive success due to burden of rare mutations HT
"strong genetic evidence that Darwin’s theory of sexual selection is shaping the gene pool of contemporary human populations"
Absolutely fascinating by , and co. exploring the relationship between reproductive success and deletion & PTV burden in LoF-intolerant genes, providing a nice explanation for why so many lack previous associations.
Sex-biased reduction in reproductive success drives selective constraint on human genes i think one of the attempts to cancel were cuz i wrote a blog post on this issue?
Currently presenting my poster on our recent preprint () on the interaction between fertility and genic constraint in the human genome at #ESHG2020. Come check it out!
"our results suggest that sexual selection can account for about a quarter of all purifying selection acting on human genes"
⁦⁩ have you seen this? Sex-biased reduction in reproductive success drives selective constraint on human genes | bioRxiv