Neuropilin-1 is a host factor for SARS-CoV-2 infection
bioRxiv 270d 5 tweets
SARS-CoV-2 is the causative agent of COVID-19, a coronavirus disease that has infected more than 6.6 million people and caused over 390,000 deaths worldwide. The Spike (S) protein of the virus forms projections on the virion surface responsible for...


Dr Gaetan Burgio, MD, PhD. 268d ago
This is an important and beautiful piece of work on #COVID19 demonstrating Neuropilin-1 is a host receptor for #SARSCoV2 cell entry via S1 CendR motif generated by the furin cleavage of S1/S2 spike (S) protein => Alternative entry pathway to ACE2 & TMPRSS2
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Yohei Yamauchi 268d ago
Two independent studies showing #COVID19 uses its furin-cleaved S1 CendR (sender) motif to hijack cell surface Neuropilin-1 in order to (1) facilitate host cell entry and (2) enhance viral spread to the CNS.
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Peter J. Cullen 270d ago
Lab preprint - NRP1 a host factor for SARS-CoV-2 infection . Fantastic effort James, Boris, Carlos , an inspiring collaboration with , Andrew Davidson and David Matthews lab’s . NRP1, a therapeutic target for COVID-19?
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Peter J. Cullen 268d ago
An exciting paper . Independent evidence proposing a role for NRP1 in SARS-CoV-2 infectivity .
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Adam Finn 263d ago
bioRxiv viewer Work from describing a new pathway of human cellular interaction by SARS CoV2 helping explain its extensive tissue tropism
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