"We conclude that death in Covid-19 is primarily a consequence of immune-mediated, rather than pathogen- mediated, organ inflammation and injury." Autopsy series confirming the path to reducing fatalities
Important Paper ! - Death in Covid-19 is primarily a consequence of immune-mediated, rather than pathogen mediated, organ inflammation and injury. Please download, read and retweet "Tissue-specific tolerance in fatal Covid-19"
Important new COVID data. Two things have recently altered my perception of the mechanisms of critical illness in COVID-19. Together, dexamethasone and this autopsy series (, Chris Lucas, ) change everything 1/n
Autopsy-based study finds a mismatch between the presence of virus & sites of inflammation within organs in fatal #COVID19 - suggesting immune response & not virus itself, are responsible for death. Read:
Really proud to share the first paper from showing the disconnect between the distribution of virus and local inflammatory responses in fatal Covid-19. A huge team effort.
Viral RNA vs inflammation - Virus dependent, viral load-independent. #COVID19 #SARSCoV2 - Data frm autopsy of actual lungs shows some slight differences to studies on BALF etc.
Report an aberrant immune response in fatal #COVID19. Lung and RE system inflamed, but virus widespread in other non-inflamed organs. How does it escape and survive at other sites? Quite a puzzle.
Tissue-specific tolerance in fatal Covid-19
Tissue-specific tolerance in fatal Covid-19 #medRxiv