New Article online now at Cell: Memory Sequencing Reveals Heritable Single-Cell Gene Expression Programs Associated with Distinct Cellular Behaviors
How can we measure the #memory of a single #cell? MemorySeq can reveal new forms of #biological memory by identifying slowly fluctuating #gene expression states in rare single #cells. Online now!
This is such a cool paper! Congrats and Ben Emert. Really beautiful work!! Memory Sequencing Reveals Heritable Single-Cell Gene Expression Programs Associated with Distinct Cellular Behaviors
Can you infer heritable single-cell gene expression from a single time-point bulk measurement? , , & colleagues introduced a cool method to do it in 2018 , and now it is published in
New from and co: Memory sequencing reveals heritable single-cell gene expression programs associated with distinct cellular behaviors. (NB: for geneticists out there 'heritability' here refers to correlated expression traits b/n cell divisions)
Chewing on this demonstration of heritable gene expression. Very clever application of methods from 1940's & 2020's suggesting a non-genetic mechanism for Rx resistance. Stochastic? Epigenetic? unknown, but certainly fascinating!
Memory Sequencing Reveals Heritable Single-Cell Gene Expression Programs Associated with Distinct Cellular Behaviors