Remarkable evolutionary innovations by primates. My favorite: a third of the interneurons in the striatum are a novel type without homolog in mouse or ferret. Excited to share this work from team led by with
taking a break from biennial tweets about sports to celebrate our paper, out today! thanks to my delightful crew of collaborators including , Guoping Feng,  labs and other friends.
Gong bong! , , large-scale systematic scRNAseq, and a starring cast of interneurons across mice, ferrets, marmoset, macaques and humans herald an exciting age for comparative neurobiology and contextualizing mouse-human translation
Krienan et al., present one of the most comprehensive comparisons of interneurons (inhibitory neurons within the CNS) across mice, humans and marmosets. Very rich dataset that will be super informative for basic and translational studies.
Not all interneurons were created equal across species. primates may have gotten an upgrade in their interneuron repertoire. More or different local computations? Good news for computational neuroscientists doing biophysical modelling of cell types
Comparative analysis of interneuron diversity by ⁦⁩ ⁦⁩ ⁦⁩ ⁦⁩ ⁦⁩ Innovations present in the primate interneuron repertoire | Nature
Innovations present in the primate interneuron repertoire
Primates are not just large mice. A team lead by discover a new striatal cell-type that is found in primates, but not mice. This suggests important species differences that extend to putatively evolutionarily conserved sub-cortical regions.