SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies
The COVID-19 pandemic presents an urgent health crisis. Human neutralizing antibodies (hNAbs) that target the host ACE2 receptor-binding domain (RBD) of the SARS-CoV-2 spike1–5 show therapeutic promise and are being evaluated clincally6–8. To...
Eric Topol
144d ago
Just published @nature
The 4 classes of neutralizing antibodies to #SARSCoV2 as determined by extensive structural biology, biophysical and bioinformatic analyses
nature.com/articles/s4158…
@Caltech pic.twitter.com/Dtgwh39REI
18
A paper in Nature reports new structures of COVID-19 patient-derived neutralizing antibodies and classifies them into four categories, suggesting combinations for clinical use. go.nature.com/374I8y1 pic.twitter.com/0EBqVYueXH
This work is a tour de force on solving the CryoEM structure of 8 human neutralizing antibodies in complex with #SARSCoV2 spike RBD & describes 4 classes of neutralization. The variability of nAb bind to spike is quite unexpected
nature.com/articles/s4158… pic.twitter.com/sH23JfkFLk
Our soon to be colleagues @cobarnes27 and @naimagsharaf and colleagues @bjorkmanlab @Caltech @RockefellerUniv report structures of nAbs bound to SARS-CoV-2 spike, revealing molecular basis of therapeutic efficacy!
#SARSCoV2 #Neutralizing_Antibody structures | inform therapeutic strategies | Pamela Bjorkman @Caltech @nature buff.ly/34PAjJX pic.twitter.com/ITOPMvh7bn
#SARSCoV2 #Neutralizing_Antibody structures | inform therapeutic strategies | Pamela Bjorkman @Caltech @nature buff.ly/34PAjJX pic.twitter.com/mHRij0LcaK
#SARSCoV2 #Neutralizing_Antibody structures | inform therapeutic strategies | Pamela Bjorkman @Caltech @nature buff.ly/34PAjJX pic.twitter.com/Je65uBjflO
