Just published The 4 classes of neutralizing antibodies to #SARSCoV2 as determined by extensive structural biology, biophysical and bioinformatic analyses
A paper in Nature reports new structures of COVID-19 patient-derived neutralizing antibodies and classifies them into four categories, suggesting combinations for clinical use.
This work is a tour de force on solving the CryoEM structure of 8 human neutralizing antibodies in complex with #SARSCoV2 spike RBD & describes 4 classes of neutralization. The variability of nAb bind to spike is quite unexpected
Our soon to be ⁦colleagues ⁦⁩ and ⁦⁩ and colleagues ⁦⁩ ⁦⁩ ⁦⁩ report structures of nAbs bound to SARS-CoV-2 spike, revealing molecular basis of therapeutic efficacy!
#SARSCoV2 #Neutralizing_Antibody structures | inform therapeutic strategies | Pamela Bjorkman
#SARSCoV2 #Neutralizing_Antibody structures | inform therapeutic strategies | Pamela Bjorkman
#SARSCoV2 #Neutralizing_Antibody structures | inform therapeutic strategies | Pamela Bjorkman