The SOLIDARITY randomized trial of 4 repurposed drugs in 11, 266 hospitalized patients with #COVID19: HCQ, Remdesivir, Interferon, Lopinavir (each vs placebo) All without effect on survival or secondary endpoints
WHO SOLIDARITY trial results are out: 11,266 hospitalized Covid-19 patients randomized in 405 hospitals in 30 countries; 1,253 deaths. None of these drugs reduced mortality: remdesivir, hydroxychloroquine, lopinavir, interferon, lopinavir+interferon
"Remdesivir, Hydroxychloroquine, Lopinavir and Interferon regimens appeared to have little or no effect on hospitalized COVID-19, as indicated by overall mortality, initiation of ventilation and duration of hospital stay."
Not the result anyone hoped for. But so important to have robust, definitive data from large randomised trials. Huge credit to everyone involved in coordinated Solidarity Trial
This is blockbuster from : 'Remdesivir, Hydroxychloroquine, Lopinavir and Interferon regimens have little or no effect on hospitalized COVID-19, as indicated by mortality, initiation of ventilation and duration of hospital stay.
WHO results from the massive SOLIDARITY trial are out The findings are pretty bleak. No discernible benefit for hydroxychloroquine, lopinavir/ritonavir, remdesivir, or interferon on any endpoint (death, ventilation, discharge)
Results of the WHO SOLIDARITY trial: 30 countries & 11,266 adults with #COVID19 randomized to Remdesivir, Hydroxychloroquine, Lopinavir, Interferon or no study drug. None of these regimens had any real benefit on mortality or length of hospital stay.
Los primeros resultados del Ensayo Mundial Solidarity evaluando tratamientos para COVID, en el que el Perú también participa. Conclusión: necesitamos seguir buscando tratamientos que sean efectivos.
Wow: Pre print of WHO randomized trial shows No Benefit of #Remdesivir on mortality, initiation of ventilation and duration of hospital stay in hospitalized #covid19 patients.The mortality findings contain most of the randomized evidence on Remdesivir.
Solidarity preliminary report now published (as pre-print) Clearly zero overall 28 d mortality benefit to remdesivir “This absolutely excludes the suggestion that Remdesivir can prevent a substantial fraction of all deaths” H/t
Who said the #hydroxychloroquine treatment for #COVID19 is innocuous and no risk? Here is the results from the SOLIDARITY trial () showing the probability effect on cardiac death at 14 and 28 days post treatment
Repurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results
Acaban de publicar los resultados (en pre-publicación) del estudio SOLIDARITY de . Remdesivir, HCQ, Interferon y Lopinavir no muestran beneficios en reducción de mortalidad por #COVID19
Great work, and a sobering reminder that drugs are not the way out of this pandemic. 1/
Repurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results #medRxiv
In the end, we will all be left only with corticosteroids. That old pal that has seen your weirdest ideas but always tapped you back and whispered: "You can always count on me" Preprint of WHO's Solidarity online today.
Solidarity #COVID19 No mortality impact Lopinavir HCQ IFN Remdesivir - including in updated meta analysis
More disappointing evidence about remdesivir and mortality in another (larger) RCT. (FYI )
Big WHO study shows little/no effect of remdesivir, lopinavir, ritonavir or interferon in COVID-19
The data is the data from SOLIDARITY: Virtually superimposable survival data for #Remdisivir vs placebo (upper left). No difference in progression to ventilation or length of stay either.
Repurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results | Unfortunately no effects of Remdesivir, hydroxychloroquine, Kaletra or interferon ⁦⁩ ⁦
*PRE-PRINT not yet peer reviewed* SOLIDARITY trial findings. What now for remdesivir?
#SOLIDARITY #PrePrint Pena porque no arrojan soluciones para e manejo de #COVID19. Pero no tanta pena, hasta alegría, de saber qué cosa NO funciona y no malgastar recursos. Contento por la iniciativa, un estudio potente en varios países en simultáneo.
Repurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results: Remdesivir, Hydroxychloroquine, Lopinavir & Interferon - little or no effect on hospitalized COVID-19 (overall mortality, initiation of ventilation & duration of hospital stay)
Antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results: Remdesivir, Chloroquine, Lopinavir and Interferon regimens - little or no effect on hospitalized COVID-19 on mortality, ventilation and hospital stay
Repurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results | Dessverre ingen effekter av Remdesivir, hydroksyklorokin, Kaletra eller interferon ⁦⁩ ⁦⁩ ⁦
RT : "Remdesivir, Hydroxychloroquine, Lopinavir and Interferon regimens appeared to have little or no effect on hospitalized COVID-19, as indicated by overall mortality, initiation of ventilation and duration of hospital stay."
Remdesivir, Hydroxychloroquine, Lopinavir and Interferon regimens appeared to have little or no effect on hospitalized #COVID19 patients, via ⁦⁩ ⁦⁩ #SolidarityTrial
Repurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results | medRxiv
New Remdesivir, Hydroxychloroquine, Lopinavir and Interferon regimens appeared to have little or no effect on hospitalized COVID-19, as indicated by overall mortality, initiation of ventilation and duration of hospital stay.
The negative results of the four repurposed drugs in SOLIDARITY is a wake up call that this strategy has not much "purpose". Repurpose have MUCH lower prior than drugs developed with the specific purpose. Let's do a better job in choosing H to the tested
Réf étude OMS solidarity Remdesivir, HCQ, Lopinavir , 11266 randomisés pas d'effet à 28 js
RT : "Remdesivir, Hydroxychloroquine, Lopinavir and Interferon regimens appeared to have little or no effect on hospitalized COVID-19, as indicated by overall mortality, initiation of ventilation and duration of hospital stay."
Before too much dicing of trials of COVID treatment, including the clear null results in the WHO Solidarity Trial (), remember the Libra/Gemini aspirin story, told first hand by Richard Peto
I have read the #solidarityTrial preprint: Its supplementary material: its posted protocol: The CRF: The final report from #ACTT1 for contrast:
Another nail in the coffin for hydroxychloroquine as a treatment for patients with COVID-19, with another large RCT (the WHO SOLIDARITY trial) out October 15, 2020
Preprint available at
Repurposed antiviral drugs for COVID-19; interim SOLIDARITY trial results via et al These repurposed Covid drugs are turning out to be big myths in non-industry sponsored trials ... 1/n
I have read the #solidarityTrial preprint: Its supplementary material: its posted protocol: The CRF: The final report from #ACTT1 for contrast:
Finally got round to reading the WHO SOLIDARITY preprint, but a lot of the interesting stuff seems to be buried in the supplement - which I can’t see any link to Anyone know how to access it?
. Solidarity-studien som norske sykehus har vært bidragsytende til er ute med resultatene. Ingen nytte påvist for medikamentene som ble testet.
Repurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results
#COVID19 interim WHO SOLIDARITY trial results- repurposed old drugs not effective.