Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection
To identify potential therapeutic targets for SARS-CoV-2 and related pathogenic coronaviruses,
Wei et al. conduct genome-wide CRISPR screens in Vero-E6 cells using SARS-CoV-2, MERS-CoV
or pseudoviruses presenting SARS-CoV-1 or -2 spike proteins....
Craig Wilen
90d ago
Excited to share our new paper out today: Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection cell.com/cell/fulltext/… @CellCellPress @Yale_LabMed @YaleIBIO @YaleMed
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Genome-wide CRISPR screens identify common entry points for multiple coronaviruses:
[1] Genome-wide CRISPR screens for pathogenic coronaviruses in Vero-E6 cells.
[2] Screens identified genes that are SARS-CoV-2-, MERS-CoV-, and pan-coronavirus-specific.
cell.com/cell/fulltext/… pic.twitter.com/Sjocqz2TMt
#Genome-wide #CRISPR screens reveal #host factors critical for #SARSCoV2 #infection. Now Online! bit.ly/3keMC9i
For all @CellPressNews #coronavirus research and commentary, visit cell.com/2019-nCOV
#COVID19 pic.twitter.com/qkekD41yoG
#SARSCoV2_Infection | Genome-wide CRISPR screens reveal critical host factors | Craig Wilen @YaleMed @CellCellPress buff.ly/37pkTis buff.ly/3macZOf pic.twitter.com/RYRRQuEx48
#SARSCoV2_Infection | Genome-wide CRISPR screens reveal critical host factors | Craig Wilen @YaleMed @CellCellPress buff.ly/37pkTis buff.ly/3macZOf pic.twitter.com/NsFmOYhevq
#SARSCoV2_Infection | Genome-wide CRISPR screens reveal critical host factors | Craig Wilen @YaleMed @CellCellPress buff.ly/37pkTis buff.ly/3macZOf pic.twitter.com/ffu319Cz0o
Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection
On a related note, my friend @JohnDoench & @WilenLab recently published a beautiful screen using a monkey-targeting (!) CRISPR library with several different coronaviruses.