Immune receptor inhibition through enforced phosphatase recruitment
A approach termed ‘receptor inhibition by phosphatase recruitment’ is described for attenuating both tonic and ligand-activated cell-surface receptor signalling.
Clever way from Garcia lab to turn off immune receptors using Abs to promote co-recruitment of receptors that activate phosphatases. Example results in improved PD-1 blockade.
Immune Regulation News
✨ New in
! Dr. Christopher Garcia and
scientists present an alternative approach for attenuating cell-surface receptor signaling, termed #ReceptorInhibition by phosphatase recruitment. #antibodies
New #anti-PD1 better than the commercially available and new method to bring receptors together....amazing stuff
Thomas Tan, Ph.D.
I'm sure we'll soon hear about a newco debuting with this technology 👉 Bispecific antibody inhibits PD-1 signaling through enforced CD45 phosphatase recruitment
#ImmuneReceptor_Inhibition | enforced CD45 phosphatase recruitment | Crosslinking of CD45 to PD-1 potentiates T cell activation | Christopher Garcia
#ImmuneReceptor_Inhibition | enforced CD45 phosphatase recruitment | reduces PD-1 phosphorylation and potentiates T cell activation | Christopher Garcia
#ImmuneReceptor_Inhibition | through enforced phosphatase recruitment | Ligand-Independent PD-1 signalling reduces T cell activation | Christopher Garcia
Paul D. Rennert
On the same journal site - groups out of
show a very clever way to tackle PD-1, "enforced phosphatase recruitment", with enhanced #immunotherapy activity in preclinical models