Why have so many patients with #COVID19 been reporting neurological symptoms? New foundational study by and Andrew Yang analyzes the first single-cell transcriptome of brains from COVID-19 patients ☀️🧠🧵1/10
“Many COVID-19 gene expression changes are shared with those in chronic brain disorders and reside in genetic variants associated with cognitive function, schizophrenia, and depression.”
"Among neurons, layer 2/3 excitatory neurons--evolutionarily expanded in humans--show a specific downregulation of genes encoding major SNARE and synaptic vesicle components, predicting compromised synaptic transmission. "