Excited to share our latest work just published in elucidating the molecular mechanism by which SARS-CoV-2 Orf6 inhibits Interferon signaling!
From the García-Sastre lab 'SARSCoV2 is able to efficiently block STAT1 and STAT2 nuclear translocation in order to impair transcriptional induction of ISGs. Our results demonstrate that the viral accessory protein Orf6 exerts this anti-IFN activity'
Part of #SARSCoV2's potency is tied to its ability to interrupt our interferon defense mechanism. A new study gets granular at to how that's accomplished (via Orf6).