Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | Blood | American Society of Hematology
Ashpublications.org 125d 1 tweets
Key Points. SARS-CoV-2 spike proteins bind heparan sulfate and activate the alternative complement pathway on cell surfaces.Factor D inhibitor (ACH-145951) blo


Toni Choueiri, MD 125d ago
Direct activation of the complement pathway by #SARSspikeproteins is blocked by factor D inhibition ⁦⁩. These proteins bind heparan sulfate on cell surface. This may explain catastrophic thrombosis with #COVID19 ⁦⁩
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