The BRCA1 Tumor Suppressor Binds to Inositol 1,4,5-Trisphosphate Receptors to Stimulate Apoptotic Calcium Release
The inositol 1,4,5-trisphosphate receptor (IP[3] R) is a ubiquitously expressed endoplasmic reticulum (ER)-resident calcium channel. Calcium release mediated by IP[3] Rs influences many signaling pathways, including those regulating apoptosis. IP[3]...