D. Russler-Germain
MD-PhD. Hematology/oncology physician-scientist-in-training. Tweet/RT not medical advice or endorsement.
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Chronic viral infection promotes early germinal center exit of B cells and impaired antibody development.
Chronic viral infections disrupt B cell responses leading to impaired affinity maturation and delayed control of viremia. Previous studies have identified early pre-germinal center (GC) B cell attrition but the impact of chronic infections on B cell...
Genomic DNA Methylation Signatures Enable Concurrent Diagnosis and Clinical Genetic Variant Classification in Neurodevelopmental Syndromes
Pediatric developmental syndromes present with systemic, complex, and often overlapping clinical features that are not infrequently a consequence of Mendelian inheritance of mutations in genes involved in DNA methylation, establishment of histone...
gerstung-lab/tensorsignatures
Tensorframework for mutational signature analysis. - gerstung-lab/tensorsignatures
Learning mutational signatures and their multidimensional genomic properties with TensorSignatures
Mutational signature analysis is an essential part of the cancer genome analysis toolkit. Conventionally, mutational signature analysis extracts patterns of different mutation types across many cancer genomes. Here we present TensorSignatures, an...
Oncologic Therapy Shapes the Fitness Landscape of Clonal Hematopoiesis
Clonal hematopoiesis (CH) is frequent in cancer patients and associated with increased risk of therapy related myeloid neoplasms (tMN). To define the relationship between CH, oncologic therapy, and tMN progression, we studied 24,439 cancer patients....
Gene expression cartography
A new computational framework, novoSpaRc, leverages single-cell data to reconstruct spatial context for cells and spatial expression across tissues and organisms, on the basis of an organization principle for gene expression.
Automated Design of Pluripotent Stem Cell Self-Organization
Libby et al. created a computational model of pluripotent stem cell (PSC) dynamics,
enabling a machine learning optimization approach to predict experimental conditions
that yield targeted multicellular patterns. These results demonstrate that...
Dynamic Imaging of RNA in Living Cells by CRISPR-Cas13 Systems
Yang et al. show that the dCas13 system is capable of labeling RNAs. Applying orthogonal
dCas13s or combining with dCas9 allows simultaneous visualization of RNA-RNA and DNA-RNA
in living cells. The dCas13 system is user friendly in real-time RNA...
Longitudinal molecular trajectories of diffuse glioma in adults
The GLASS Consortium studies the evolutionary trajectories of 222 patients with a diffuse glioma to aid in our understanding of tumour progression and treatment failure
Consensus molecular subgroups (CMS) of colorectal cancer (CRC) and 1 st -line efficacy of FOLFIRI plus cetuximab or bevacizumab in the FIRE3 (AIO KRK-0306) trial
AbstractIntroduction. FIRE-3 compared 1st-line therapy with FOLFIRI plus either cetuximab or bevacizumab in 592 KRAS exon 2 wild-type mCRC patients. The Consen
The mutational footprints of cancer therapies
Analysis of whole-genome sequences from more than 3,500 metastatic tumors identifies mutational signatures associated with different chemotherapies and provides estimates of the relative contribution of different treatments to tumor mutational...
Differences in Tumor Microenvironment Dictate T Helper Lineage Polarization and Response to Immune Checkpoint Therapy
The response to immune checkpoint therapy in a subset of patients with castration-resistant
prostate cancer who develop bone metastases can be improved by promoting CD4 Th1 effector
T cell responses and clonal expansion of CD8 T cells through TGF-β...
Circular ecDNA promotes accessible chromatin and high oncogene expression
Imaging and sequencing approaches are combined to show that extrachromosomal DNA (ecDNA) in cancer is circular and has unique chromatin structure that amplifies oncogene output.
BET inhibition disrupts transcription but retains enhancer-promoter contact
In higher eukaryotes, enhancers are DNA sequences that enable complex temporal and tissue-specific regulation of genes. Although it is not entirely clear how enhancer-promoter interactions can increase gene expression, this proximity has been...
Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses
Programmed cell death 1 (PD-1) is an inhibitory receptor that normally keeps T cell immune responses in check. Immunotherapy targeting PD-1 has proven successful for certain types of cancer, but it remains unclear how PD-1 is regulated. Sugiura et...
PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways
Combined immunotherapy targeting the checkpoint receptors CTLA-4 and PD-1, or CTLA-4
and the PD-1 ligand (PD-L1) results in superior anti-tumor responses. Zhao et al.
show that PD-L1 heterodimerizes with CD80, a shared ligand for CTLA-4 and CD28,...