D. Russler-Germain
MD-PhD. Hematology/oncology physician-scientist-in-training. Tweet/RT not medical advice or endorsement.
Last synced from Twitter 4m ago
clara-parabricks/rapids-single-cell-examples
Examples of single-cell genomic analysis accelerated with RAPIDS - clara-parabricks/rapids-single-cell-examples
American Society of Hematology 2020 guidelines for treating newly diagnosed acute myeloid leukemia in older adults | Blood Advances | American Society of Hematology
AbstractBackground:. Older adults with acute myeloid leukemia (AML) represent a vulnerable population in whom disease-based and clinical risk factors, patient
Control of Viral Infection by Natural Killer Cell Inhibitory Receptors
Parikh et al. show that major histocompatibility complex class I (MHC-I)-restricted
control of viral infection is due to natural killer (NK) cells rather than cytotoxic
T cells. Inhibitory NK cell receptors are essential for protection, requiring NK...
Donald Trump Has Given America Its Best Chance to Defeat Racism
The president has revealed the depths of the country’s prejudice—and forced Americans to reckon with a racist system.
DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers
A new statistical framework to classify mutagenesis clusters identifies a novel, diffuse hypermutation pattern, named omikli, that is induced by APOBEC3 and associated with mismatch-repair activity.
Do, Share, Teach, and Learn Data Science with RStudio Cloud
RStudio is proud to announce the general availability of RStudio Cloud, its cloud-based platform for doing, teaching, and learning data science. WIth RStudio Cloud, there's nothing to configure and no dedicated hardware or installation required....
TargetCancer Foundation Announces Rare Cancer Precision Medicine Research Initiative
TargetCancer Foundation (TCF) proudly announced today the initiation of the TCF-001 TRACK (Target Rare Cancer Knowledge) Study, an innovative trial th
The Pandemic’s Biggest Mystery Is Our Own Immune System
Which is too bad because the immune system is very complicated.
Optimizing Cancer Treatment Using Game Theory
This review approaches cancer treatment as a game theoretic contest between the physician’s therapy and the cancer cells’ resistance strategies and suggests how treatment strategies can be improved by exploiting the critical asymmetries between the...
Bortezomib, Melphalan, and Dexamethasone for Light-Chain Amyloidosis
PURPOSE Oral melphalan and dexamethasone (MDex) were considered a standard of care in light-chain (AL) amyloidosis. In the past decade, bortezomib has been increasingly used in combination with alkylating agents and dexamethasone. We prospectively...
Two decades of pandemic war games failed to account for Donald Trump
The scenarios foresaw leaky travel bans, a scramble for vaccines and disputes between state and federal leaders, but none could anticipate the current levels of dysfunction in the United States.
Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab
Siu and colleagues use a bespoke ctDNA assay and show predictive utility of longitudinal ctDNA analysis in a phase II clinical trial of patients receiving pembrolizumab that included multiple solid tumor types.
Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes
Clinical sequencing across a large prospective cohort of patients with myelodysplasic syndrome uncovers distinct associations between the mono- and biallelic states of TP53 and clinical presentation
Home - Personalis
Personalis, Inc. is a cancer genomics company transforming the development of next-generation therapies by providing more comprehensive molecular data about each patient’s cancer and immune response. The company’s NeXT Platform is designed to adapt...
Osimertinib-Bevacizumab Effects on Progression-Free Survival in Patients With Metastatic EGFR-Mutant Lung Cancers
This interventional clinical trial examines the safety and tolerability of osimertinib and bevacizumab combination treatment and assesses the 12-month progression-free survival of the combination in patients with metastatic EGFR-mutant lung cancers.
NK cells: energized yet exhausted in adult HLH | Blood | American Society of Hematology
In this issue of Blood, Carvelli et al comprehensively analyze the immunologic and genetic features of a large cohort of adults with hemophagocytic lymphohistio