D. Russler-Germain
MD-PhD. Hematology/oncology physician-scientist-in-training. Tweet/RT not medical advice or endorsement.
Last synced from Twitter 5m ago
Management of Patients With Acute Ischemic Stroke
This JAMA Clinical Guidelines Synopsis describes the 2018 American Heart Association/American Stroke Association guidelines for management of patients with acute ischemic stroke.
Adjuvant Trastuzumab for 9 Weeks vs 1 Year With Chemotherapy for Early HER2-Positive Breast Cancer
This randomized clinical trial evaluates the efficacy and safety of adjuvant trastuzumab continued beyond chemotherapy for a duration of 9 weeks vs 1 year in women with HER2-positive early breast cancer treated with up-front chemotherapy containing...
Steroid Side Effects
This JAMA Patient Page describes use of steroid medications and the side effects that can result.
Spatial metagenomic characterization of microbial biogeography in the gut
The spatial distribution of bacterial species in the mouse gut is measured by microscopic ‘plot sampling’.
Landscape of transcriptomic interactions between breast cancer and its microenvironment
The transcriptomic profile of tumour-adjacent cells provides important information about tumour context but its clinical utility is unclear. Here, in breast cancer, Fox et al. show that the mRNA abundances of tumour and tumour-adjacent cells hold...
The roles of DNA, RNA and histone methylation in ageing and cancer
The dynamic methylation of chromatin components — DNA, histones and RNA — is crucial in development, ageing and cancer. Therapies that target regulators of DNA and histone methylation in cancer have recently been developed. These promising...
Stress Testing–Induced Myocardial Ischemia and Clinical Events in Patients With Multivessel CAD
This cohort study uses MASS II trial data to assess the association of myocardial ischemia documented during exercise stress testing with major adverse cardiovascular events or changes in the ventricular function in patients with multivessel...
A Note From Salt Lake City
Readers will no doubt recall my post last week on stem cell clinics. It seems to have achieved a wide audience - wide enough to include the legal profession, at any rate. Below are copies of a letter I have recently received, and what better place...
USA TODAY's Editorial Board: Trump is 'unfit for the presidency'
The Editorial Board has never taken sides in the presidential race. We're doing it now.
Durvalumab With or Without Tremelimumab for Patients With Metastatic Pancreatic Adenocarcinoma
This phase 2 randomized clinical trial assesses the safety and efficacy of durvalumab with and without tremelimumab for the treatment of patients with metastatic pancreatic ductal adenocarcinoma.
R-CHOP preceded by blood-brain barrier permeabilization with engineered tumor necrosis factor-α in primary CNS lymphoma
There is a [ Blood Commentary][1] on this article in this issue.
[1]: /lookup/doi/10.1182/blood.2019001383
Oncology and Primary Care Collaboration for Chronic Comorbitity Treatment Among Patients With Cancer
This Viewpoint explores the value of collaboration between oncologists and primary care physicians in caring for patients with cancer, particularly those with chronic comorbidities.
“Double-hit” follicular lymphoma
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A 93-year-old woman presented with axillary lymphadenopathy. A biopsy showed lymphoid tissue with vaguely nodular architecture. Within the nodule, there was sheet of exclusive large centroblasts with few centrocytes in between...
Charting a tissue from single-cell transcriptomes
Massively multiplexed sequencing of RNA in individual cells is transforming basic and clinical life sciences. However, in standard experiments, tissues must first be dissociated. Thus, after sequencing, information about the spatial relationships...
H3K4me3 is neither instructive for, nor informed by, transcription.
H3K4me3 is a near-universal histone modification found predominantly at the 5' region of genes, with a well-documented association with gene activity. H3K4me3 has been ascribed roles as both an instructor of gene expression and also a downstream...
Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia
Ex vivo drug testing is a promising approach to identify novel treatment strategies for acute myeloid leukemia. However, accurate blast-specific drug responses cannot be measured with homogeneous "add-mix-measure" cell viability assays. In this...
Bioinformatic methods for cancer neoantigen prediction
Tumor cells accumulate aberrations not present in normal cells, leading to presentation of neoantigens on MHC molecules on their surface. These non-se…
Immune-boosting compound makes immunotherapy effective against pancreatic cancer
Chemical compound extends survival by months, in mice