D. Russler-Germain
MD-PhD. Hematology/oncology physician-scientist-in-training. Tweet/RT not medical advice or endorsement.
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WSJ News Exclusive | Trump Repeatedly Pressed Ukraine President to Investigate Biden’s Son
President Trump in a July phone call repeatedly pressured the president of Ukraine to investigate Democratic presidential candidate Joe Biden’s son, urging Volodymyr Zelensky about eight times to work with Rudy Giuliani, his personal lawyer, on a...
NLRB Proposal Would Make Student Workers Ineligible to Unionize
Graduate teaching assistants and other student workers at private universities and colleges wouldn’t qualify for federal protections that grant most private-sector workers the right to form or join a union under a new regulatory proposal.
Predictive value of interim FDG-PET/CT findings in patients with diffuse large B-cell lymphoma treated with R-CHOP. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
cellHarmony: cell-level matching and holistic comparison of single-cell transcriptomes
Abstract. To understand the molecular pathogenesis of human disease, precision analyses to define alterations within and between disease-associated cell popula
PD-L2 in follicular lymphoma: Sidekick or star?
Immune profiling of follicular lymphoma reveals a role for PD-L2 expression in predicting early progression and survival.
Organization of Chromatin by Intrinsic and Regulated Phase Separation
Eukaryotic chromatin is highly condensed but dynamically accessible to regulation and organized into subdomains. We demonstrate that reconstituted chr…
Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies
Guièze et al. show that resistance to the BCL-2 inhibitor venetoclax in chronic lymphocytic
leukemia is associated with complex clonal shifts and identify, in addition to the
known involvement by BCL-2 family members, regulators of lymphoid...
School of Medicine receives award to develop physician-scientists
Burroughs Wellcome Fund institutional award aims to boost number of doctors who also conduct research
Anticoagulation for Subsegmental Pulmonary Embolism | NEJM
Clinical Decisions from The New England Journal of Medicine — Anticoagulation for Subsegmental Pulmonary Embolism
Distinct immune composition in lymph node and peripheral blood of CLL patients is reshaped during venetoclax treatment
Morbidity and mortality due to immunosuppression remain among the foremost clinical challenges in chronic lymphocytic leukemia (CLL). Although immunosuppression is considered to originate within the lymph node (LN) microenvironment, alterations in T...
Adding Ovarian Suppression to Tamoxifen for Premenopausal Breast Cancer: A Randomized Phase III Trial
PURPOSE The addition of ovarian function suppression (OFS) for 5 years to tamoxifen (TAM) for treatment of premenopausal patients with breast cancer after completion of chemotherapy has beneficial effects on disease-free survival (DFS). This study...
Finding the Right Words to Stop Cancer Screening in Older Adults
In this Medical News article, experts discuss sensitive ways to tell older adults that they no longer need cancer screening when their life expectancy is less than 10 years.
Epidemiology and outcomes of marked elevations of alanine aminotransferase >1000 IU/L in an Australian cohort
Common causes of marked alanine aminotransferase derangement include liver ischemia, drugs/toxins, biliary obstruction, and viral hepatitis. Determination of etiology and outcomes of patients...
Low‐dose methotrexate: potential clinical impact on haematological and constitutional symptoms in myeloproliferative neoplasms
The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.
MARS: Mutation-Adjusted Risk Score for Advanced Systemic Mastocytosis
PURPOSE To develop a risk score for patients with advanced systemic mastocytosis (AdvSM) that integrates clinical and mutation characteristics. PATIENTS AND METHODS The study included 383 patients with AdvSM from the German Registry on Disorders of...
Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention
O'Connor et al. show that lymphoma cells (LCs) enter the brain but quickly exit along
an endothelial CXCL12 gradient, which is countered by astrocyte-derived CCL19. Aged
and gliotic brains express more CCL19 and thus retain LCs longer, conferring an...