D. Russler-Germain
MD-PhD. Hematology/oncology physician-scientist-in-training. Tweet/RT not medical advice or endorsement.
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Engineered peptide barcodes for in-depth analyses of binding protein libraries
A method for protein binder selection and identification, NestLink, uses barcoding peptides detectable by mass spectrometry to select and biophysically characterize thousands of binders without requiring the handling of individual clones.
Gemcitabine, Cisplatin, and nab-Paclitaxel for Patients With Advanced Biliary Tract Cancer
Biliary tract cancers (BTCs) are rare gastrointestinal malignant neoplasms, with nearly 6000 cases diagnosed each year in the United States, but outcomes for th
STREAM
Single-cell Trajectories Reconstruction Exploration And Mapping
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STREAM: Single-cell Trajectories Reconstruction, Exploration And Mapping of single-cell data - pinellolab/STREAM
Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM
The increasing accessibility of single cell omics technologies beyond transcriptomics demands parallel advances in analysis. Here, the authors introduce STREAM, a pipeline for reconstruction and visualization of differentiation trajectories from...
Viral, immunologic, and clinical features of primary effusion lymphoma
Primary effusion lymphoma (PEL) is an aggressive HIV-associated lymphoma with a relatively poor prognosis in the era of effective HIV therapy. Kaposi sarcoma herpesvirus (KSHV) is the etiologic agent, and ∼80% of tumors are coinfected with...
Differential Safety in Top-Ranked Cancer Hospitals and Their Affiliates
This cross-sectional study compares perioperative mortality of Medicare beneficiaries after complex cancer surgery at top-ranked cancer hospitals vs their affiliated hospitals.
Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state
Triple-negative breast cancer is an aggressive malignancy that is not susceptible to hormone inhibition and must therefore be treated with conventional chemotherapy. This includes neoadjuvant chemotherapy, where the treatment is initiated before...
Use of Metformin for Type 2 Diabetes in 2019
This JAMA Insights Clinical Update reviews the clinical use, safety, contraindications, and alternatives to metformin, the first-line treatment for type 2 diabetes.
U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies
Smith et al demonstrate that mutated splicing factor U2AF1 promotes expression of a longer isoform of IRAK4, leading to enhanced NF-kB activation and leukaemic growth in acute myeloid leukaemia.
Establishing and Maintaining a Robust Sample Management System
This paper has been written by the SLAS Sample Management Special Interest Group to serve as a guide to the best practices and methods in establishing and maint...
Taking a “BiTE out of ALL”: blinatumomab approval for MRD-positive ALL
Blinatumomab, a bispecific T-cell engager (BiTE) associated with improved survival in relapsed or refractory acute lymphoblastic leukemia (ALL), was recently approved for treatment of minimal residual disease (MRD). MRD is an important predictor of...
Splicing the innate immune signalling in leukaemia
Components of the spliceosome are frequently mutated in haematopoietic malignancies. Identification of mis-spliced genes promoting transformation will uncover novel targeted therapies. Now, a long isoform of IRAK4 is shown to be upregulated in a...
Immunogenic neoantigens derived from gene fusions stimulate T cell responses
Fusion proteins in cancers with low mutational burden represent functional neoantigens that elicit T cell activation and mediate responses to immunotherapy.
Multiplexed detection of proteins, transcriptomes, clonotypes and CRISPR perturbations in single cells
ECCITE-seq combines the single-cell analysis of multiple modalities, for example transcriptome, immune cell receptors, cell surface proteins and single-guide RNAs.