D. Russler-Germain
MD-PhD. Hematology/oncology physician-scientist-in-training. Tweet/RT not medical advice or endorsement.
Last synced from Twitter 85d ago
Fatty acid metabolism underlies venetoclax resistance in acute myeloid leukemia stem cells
Jordan and colleagues show the role of increased fatty acid metabolism in AML stem cells, in both intrinsic and acquired resistance to combination venetoclax and azacitidine, and find that cells can be re-sensitized by inhibiting fatty acid...
A new neutrophil subset promotes CNS neuron survival and axon regeneration
Segal and colleagues identify a neuroprotective immature-like neutrophil subset that participates in dectin-1-dependent axon repair and regeneration in the central nervous system.
A Single-Cell Tumor Immune Atlas for Precision Oncology
The tumor immune microenvironment is a main contributor to cancer progression and a promising therapeutic target for oncology. However, immune microenvironments vary profoundly between patients and biomarkers for prognosis and treatment response...
Precision medicine treatment in acute myeloid leukemia using prospective genomic profiling: feasibility and preliminary efficacy of the Beat AML Master Trial
Preliminary results from the Beat AML umbrella trial demonstrates the feasibility and efficacy of applying prospective genomic profiling for matching newly diagnosed patients with AML with targeted therapies.
A Potential Role for Stress-Induced Microbial Alterations in IgA-Associated Irritable Bowel Syndrome with Diarrhea
Rengarajan et al. show that stress in mice causes fecal dysbiosis, which is sufficient
to induce diarrhea, intestinal barrier defect, and increased antibacterial IgA. IBS-D
patients also display fecal dysbiosis and increased antibacterial IgA that...
TGF-β suppresses type 2 immunity to cancer
Depletion of transforming growth factor-β receptor 2 (TGFBR2) in CD4+ T cells results in IL-4-dependent vascular remodelling, stopping tumour growth in a transgenic mouse model of breast cancer, suggesting that type 2 immunity could be targeted for...
ADAMTS13 Reflex ,citrate plasma - Barnes-Jewish Hospital
D. Russler-Germain
I'll give a shout out to the @BarnesJewish Hospital lab for recently implementing in-house ADAMTS13 testing, with potential for same-day turnaround depending on the clinical situation. bjhlab.testcatalog.org/show/LAB4110 (fyi @VPrasadMDMPH)
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Multiplicity in oncology randomised controlled trials: a threat to medical evidence? - PubMed
Multiplicity in oncology randomised controlled trials: a threat to medical evidence?
Adjuvant Sorafenib for Renal Cell Carcinoma at Intermediate or High Risk of Relapse: Results From the SORCE Randomized Phase III Intergroup Trial
PURPOSE SORCE is an international, randomized, double-blind, three-arm trial of sorafenib after surgical excision of primary renal cell carcinoma (RCC) found to be at intermediate or high risk of recurrence. PATIENTS AND METHODS We randomly assigned...
Arizona Is Ready to Toss Trump — and the Rest of the GOP
In the waning days of the election, Jeff Flake sees a Democratic tide coming to sweep over the state that elected him, McCain, and Goldwater.
2-Oxoglutarate-dependent dioxygenases in cancer
This Review discusses the metabolic regulation of 2-oxoglutarate-dependent dioxygenases (2OGDDs) and how dysregulation of 2OGDDs in cancer, by genetic aberrations or environmental factors including hypoxia and/or the action of oncometabolites, can...
HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis
The immunopeptidome presented by HLA-DR15 molecules links the most important genetic
and environmental risk factors for multiple sclerosis, the HLA-DR15 haplotype and
Epstein-Barr virus, by shaping a cross-reactive CD4+ T cell repertoire.
A multimodal cell census and atlas of the mammalian primary motor cortex
We report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex (MOp or M1) as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of...
Immune receptor inhibition through enforced phosphatase recruitment
A approach termed ‘receptor inhibition by phosphatase recruitment’ is described for attenuating both tonic and ligand-activated cell-surface receptor signalling.
Rudy Giuliani faces questions after compromising scene in new Borat film
Trump’s personal attorney has indiscreet encounter with actor playing Borat’s daughter in hotel room during pandemic
Additive effects of green tea and coffee on all-cause mortality in patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry
Introduction The impact of consuming green tea or coffee on mortality in patients with diabetes is controversial. We prospectively investigated the impact of each beverage and their combination on mortality among Japanese patients with type 2...