Rick Adams
Psychiatrist & scientist at UCL, working on psychosis, brain imaging, computational models of the brain. Views were probably someone else's first.
Last synced from Twitter 17m ago
What is the test-retest reliability of common task-fMRI measures? New empirical evidence and a meta-analysis
Identifying brain biomarkers of disease risk is a growing priority in neuroscience. The ability to identify meaningful biomarkers is limited by measurement reliability; unreliable measures are unsuitable for predicting clinical outcomes. Measuring...
Aberrant cortical ensembles and schizophrenia-like sensory phenotypes in setd1a mice.
A breakdown of synchrony within neuronal ensembles leading to destabilization of network
“attractors” could be a defining aspect of neuropsychiatric diseases like schizophrenia
(SZ), representing a common downstream convergence point for the diverse...
Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats
Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis. Here, using [11C]UCB-J PET, the authors show for the first time in vivo that levels of the synaptic marker protein SV2A are reduced in schizophrenia and...
Mechanisms underlying gain modulation in the cortex
Changes in cortical gain enable neurons to respond adaptively to changing inputs. In this Review, Ferguson and Cardin describe the mechanisms that modulate cortical gain, and its effects on and relevance for cognition and behaviour.
Comparing meta-analyses and preregistered multiple-laboratory replication projects
Kvarven, Strømland and Johannesson compare meta-analyses to multiple-laboratory replication projects and find that meta-analyses overestimate effect sizes by a factor of almost three. Commonly used methods of adjusting for publication bias do not...
Dopamine modulates paranoid social inferences: a double-blind, within-subject, randomised control study in a healthy population.
Altered dopamine transmission is thought to influence the formation of persecutory delusions. However, despite extensive evidence from clinical studies there is little experimental evidence on how modulating the dopamine system changes social...
Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis
Marked differences exist between antipsychotics in terms of metabolic side-effects,
with olanzapine and clozapine exhibiting the worst profiles and aripiprazole, brexpiprazole,
cariprazine, lurasidone, and ziprasidone the most benign profiles....
A large-scale standardized physiological survey reveals functional organization of the mouse visual cortex
By comparing neural responses to diverse visual stimuli measured with a standardized two-photon imaging pipeline, the authors reveal response specializations within the mouse visual cortex.
The Brainless Slime That Can Learn By Fusing
Physarum molds have no neurons, but they can solve mazes and make decisions. And by merging together, they can share memories.
The neural and molecular basis of working memory function in psychosis: a multimodal PET-fMRI study
The neural and molecular basis of working memory function in psychosis: a multimodal PET-fMRI study
The revised Green et al., Paranoid Thoughts Scale (R-GPTS): psychometric properties, severity ranges, and clinical cut-offs | Psychological Medicine
The revised Green et al., Paranoid Thoughts Scale (R-GPTS): psychometric properties, severity ranges, and clinical cut-offs - Daniel Freeman, Bao S. Loe, David Kingdon, Helen Startup, Andrew Molodynski, Laina Rosebrock, Poppy Brown, Bryony Sheaves,...
UCL Wellcome 4-year PhD in Mental Health Science
The UCL Wellcome 4-year PhD in Mental Health Science is an opportunity for students to train in a wide range of fields relevant to mental health research.
Neuro-computational account of arbitration between imitation and emulation during human observational learning
In observational learning (OL), organisms learn from observing the behavior of others. There are at least two distinct strategies for OL. Imitation involves learning to repeat the previous actions of other agents, while in emulation, learning...
Petition to Society for Neuroscience to Act on the Climate Crisis
October 31st, 2019.
TO: The Council of the Society for Neuroscience (SfN)
FROM: Members of SfN (current and recently active)
As members of SfN, we are proud of our society’s legacy of scientific excellence and leadership that was vividly on...
A circuit mechanism for irrationalities in decision-making and NMDA receptor hypofunction: behaviour, computational modelling, and pharmacology
Decision-making biases can be systematic features of normal behaviour, or deficits underlying neuropsychiatric symptoms. We used behavioural psychophysics, spiking-circuit modelling and pharmacological manipulations to explore decision-making biases...
Broadband Signal Rather than Frequency-Specific Rhythms Underlies Prediction Error in the Primate Auditory Cortex
Detection of statistical irregularities, measured as a prediction error response, is fundamental to the perceptual monitoring of the environment. We studied whether prediction error response is generated by neural oscillations or asynchronous...
Finding the imposter: brain connectivity of lesions causing delusional misidentifications
See McKay and Furl (doi:10.1093/aww323) for a scientific commentary on this article.How a focal brain injury can lead to Capgras Syndrome, the delusion that a f