Rick Adams
Psychiatrist & scientist at UCL, working on psychosis, brain imaging, computational models of the brain. Views were probably someone else's first.
Last synced from Twitter 127d ago
Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes
Autism Spectrum Disorder (ASD) is characterized by substantial, yet highly heterogeneous abnormalities in functional brain connectivity. However, the origin and significance of this phenomenon remain unclear. To unravel ASD connectopathy and relate...
Sub-second Dopamine and Serotonin Signaling in Human Striatum during Perceptual Decision-Making
Dopamine and serotonin have traditionally been linked to reward processing. Bang,
Kishida et al. show in the human brain that these neuromodulators also play a role
in non-reward-based aspects of cognition and behavior, including rapid...
eIF2α controls memory consolidation via excitatory and somatostatin neurons
Stimulation of de novo protein synthesis in both excitatory and inhibitory, somatostatin-expressing neurons in the mouse hippocampus enhances memory consolidation.
Rational Inattention and Tonic Dopamine
Slow-timescale (tonic) changes in dopamine (DA) contribute to a wide variety of processes in reinforcement learning, interval timing, and other domains. Furthermore, changes in tonic DA exert distinct effects depending on when they occur (e.g.,...
Predictive Maps in Rats and Humans for Spatial Navigation
Much of our understanding of navigation has come from the study of rats, humans and simulated artificial agents. To date little attempt has been made to integrate these approaches into a common framework to understand mechanisms that may be shared...
Convergent molecular, cellular, and cortical neuroimaging signatures of major depressive disorder
Major depressive disorder is a debilitating condition with diverse neuroimaging correlates, including cortical thinning in medial prefrontal cortex and altered functional connectivity of cortical association networks. However, the molecular bases of...
Yale Researchers to Lead $52M Investigation Into Cause, Effect of Schizophrenia in Some High-Risk Adolescents
Researchers with the Yale Department of Psychiatry will lead an international investigation to better understand the cause and effect of schizophrenia in some high-risk adolescents and young adults.
Mapping Brain-Behavior Space Relationships Along the Psychosis Spectrum
Difficulties in advancing effective patient-specific therapies for psychiatric disorders highlights a need to develop a neurobiologically-grounded, quantitatively stable mapping between neural and symptom variation. This gap is particularly acute...
Michael Sandel: 'The populist backlash has been a revolt against the tyranny of merit'
The philosopher believes the liberal left’s pursuit of meritocracy has betrayed the working classes. His new book argues for a politics centred on dignity
Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia
Stein, Barbosa et al. show that anti-NMDAR encephalitis and schizophrenia are characterized by reduced serial dependence in spatial working memory. Cortical network simulations show that this can be parsimoniously explained by a reduction in...
Medicine and Public Health
In the medicine and health areas, the advent of big data and artificial intelligence brings about enormous opportunities and challenges. Challenges include but are by no means limited to access to and quality of big data, the mechanics of data...
Tapering Antipsychotic Treatment
This Viewpoint discusses principles for tapering antipsychotic treatment when deprescribing them.
Autistic traits, but not schizotypy, predict increased weighting of sensory information in Bayesian visual integration - PubMed
Recent theories propose that schizophrenia/schizotypy and autistic spectrum disorder are related to impairments in Bayesian inference that is, how the brain integrates sensory information (likelihoods) with prior knowledge. However existing accounts...
Rick Adams
@PhilCorlett1 @joosthaarsma @lena_pl @gk_murray @kjmjDiederen @KingsIoPPN @psychiatry_ucam @CPFT_Research @CamNeuro you can do it even without laminar fMRI... (interesting discussion btw!)
pubmed.ncbi.nlm.nih.gov/29757142/
although their finding in subjects with a longstanding Scz diagnosis is hard to interpret (priors of normal precision that seem weaker when stimulus absent)
pubmed.ncbi.nlm.nih.gov/31257444/
213d
Acquisition of visual priors and induced hallucinations in chronic schizophrenia - PubMed
Prominent theories suggest that symptoms of schizophrenia stem from learning deficiencies resulting in distorted internal models of the world. To test these theories further, we used a visual statistical learning task known to induce rapid implicit...
Rick Adams
@PhilCorlett1 @joosthaarsma @lena_pl @gk_murray @kjmjDiederen @KingsIoPPN @psychiatry_ucam @CPFT_Research @CamNeuro you can do it even without laminar fMRI... (interesting discussion btw!)
pubmed.ncbi.nlm.nih.gov/29757142/
although their finding in subjects with a longstanding Scz diagnosis is hard to interpret (priors of normal precision that seem weaker when stimulus absent)
pubmed.ncbi.nlm.nih.gov/31257444/
213d
Global reward state affects learning and activity in raphe nucleus and anterior insula in monkeys
Wittmann and colleagues show that not only single outcome events but also the global reward state (GRS) impact learning in macaques; low GRS drives explorative choices. Analyses of macaque BOLD signal reveals that GRS impacts activity in the...
Investigating cortico‐subcortical circuits during auditory sensory attenuation: A combined magnetoencephalographic and dynamic causal modeling study
Rick Adams
In predictive coding these amplifying and attenuating effects are seen as effects of attention and expectations respectively (as @PeterKokNeuro & @flodlan and others have also shown). Striking that the former happens even in thalamus. Nice work Lingling!
218d
The cannabinoid 1 receptor in schizophrenia
Converging lines of evidence from epidemiological, preclinical, and experimental studies
indicate that the endocannabinoid system may be involved in the pathophysiology of
schizophrenia and suggest that the cannabinoid receptor 1 may be a potential...