Understanding the antibody response is critical to developing vaccine and antibody−based therapies and has inspired the recent development of new methods to isolate antibodies. However, methods to define the antibody-antigen interactions that...
A cladogram is an unrooted tree with labeled leaves and unlabeled internal branchpoints of degree 3. Aldous has studied a Markov chain on the set of n-leaf cladograms in which each transition consists of removing a random leaf and its incident edge...
(Fred)erick Matsen@ianholmes I don't know of anything that incorporates a data likelihood. Even the data-free problem is very hard! This might be a good place to start looking at references
There are a lot of unknowns in the world right now. But one thing is certain — Headspace is here for you. To help you, we’re offering some meditations you can listen to anytime.
(Fred)erick MatsenBe well.
I have used the meditation/mindfulness @headspace app for over 3 years now, and found it to be very effective in keeping anxiety at bay. Now they have a limited free offering for everyone, as well as free complete access for healthcare workers
(Fred)erick MatsenI'm giving my promotion talk on March 24th at 9am PT about variational Bayesian phylogenetics as well as various B cell receptor repertoire projects. I'll be streaming it to YouTube
(Fred)erick MatsenI'll be streaming my promotion talk in 1 hour, on new methods for Bayesian phylogenetics (useful for tracking viruses) and B cell adaptive immunology (hopefully useful for designing vaccines for difficult-to-neutralize viruses)
r/Crostini: A forum for discussion and discovery for using VMs, Containers, and related tools on Chrome OS & Chromium. This community was created by …
(Fred)erick Matsen+ no more distro maintenance = more time for ♥️
+ responsive, lightweight os
+ fanless = silent
+ superb battery life, even after constant use
+ can install any Android app
- I'd rather run a free linux
- I do have to reboot ~ every 2 weeks
Come use work with us to learn about the immune system through sequencing and computational analysis.
(Fred)erick MatsenWe're looking for a postdoc who loves stats/machine learning and is interested in immunology, or who loves immunology and wants to grow computationally. matsen.fredhutch.org/general/2020/0… Fun problems + great collabs + welcoming & energetic environment.
Antibody affinity maturation reconstructions are uncertain. Let's take that into account.
(Fred)erick MatsenA "lay" summary of our recent Bayesian phylogenetic hidden Markov model for B cell receptor (i.e. antibody) sequences: matsen.fredhutch.org/general/2020/0… .
Immunological take-home: if you are doing expensive experiments based on computational reconstructions, don't rely on point estimates.
Cryo-electron microscopy (cryo-EM) is a powerful technique for determining
the structure of proteins and other macromolecular complexes at near-atomic
resolution. In single particle cryo-EM, the central problem is to reconstruct