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Weakly supervised classification of aortic valve malformations using unlabeled cardiac MRI sequences
The availability of labelled training data is one of the practical obstacles towards wide application of machine learning models in medicine. Here the authors develop a weakly supervised deep learning model for the classification of aortic...
Donate Now: Euan's clan runners! - on GroupRev
Euan Ashley is using the free crowdfundraising website GroupRev to raise money for Euan's clan runners! - Help fundraise for the Stanford Medicine MyHeart Counts 5K, 10K, & Kids Run on Sunday, September 8, 2019 – our annual walk/run celebrating...
euan ashley
Make your own team or join mine!
Not near Stanford? You can donate to Euan's Clan Runners!
19d
Social-network-like gene connections identified in heart failure
A Stanford-led research team has mapped out a network of gene activity before and after heart failure to better understand how heart health declines.
Heart Failure Regulatory Gene Revealed in Tissue Transcriptome Study
Using samples from heart failure patients and healthy controls, researchers uncovered a gene that, when absent in mice, reduced their risk of heart failure.
Gene networks reveal transition from healthy to failing heart
A Stanford-led research team has mapped out a network of gene activity before and after heart failure to better understand how heart health declines.
euan ashley
Gene networks reveal transition from healthy to failing heart buff.ly/2J5OmAb pic.twitter.com/fp1BecJ7gG
27d
Heart Failure eQTLs companion to "Pathologic gene network rewiring implicates PPP1R3A as a central cardioprotective factor in pressure overload heart failure"
These are the results of a QTL analysis companion to "Pathologic gene network rewiring implicates PPP1R3A as a central cardioprotective factor in pressure overload heart failure". We performed RNA expression measurements and obtained genotype...
euan ashley
5/ Likely due to rapid tissue preservation, we found many new eQTLs and network eQTLs (thanks for collaboration to @sbmontgom) zenodo.org/record/2617028… pic.twitter.com/ZtJthhWjwB
27d
Gene interaction networks from donor and failing heart gene expression
These are the gene-gene interaction networks obtained from gene expression microarray data in the paper "Pathologic gene network rewiring implicates PPP1R3A as a central cardioprotective factor in pressure overload heart failure" by Cordero, Parikh,...
euan ashley
4/ We used chip based genotyping/gene expression assays and applied multiple network methods (WCGNA, Lasso, ARACNe, Pearson). Results were consistent. Data and networks are freely available. zenodo.org/record/2600420… pic.twitter.com/wQzdLcDQbB
27d
Heart Failure Fact Sheet|Data & Statistics|DHDSP|CDC
euan ashley
2/ Heart failure is a major and growing cause of death around the world. Current therapies are aimed at tempering the physiological response to disease, rather than the cardiac muscle itself cdc.gov/dhdsp/data_sta… pic.twitter.com/ignG9js6hd
27d
Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure
The genetic and pathogenetic basis of heart failure is incompletely understood. Here, the authors present a high-fidelity tissue collection from rapidly preserved failing and non-failing control hearts which are used for eQTL mapping and network...
euan ashley
1/n New paper from our group today nature.com/articles/s4146… pic.twitter.com/HzI6BjOS8v
27d
Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism
A closer look at the gut microbiome of elite marathon runners unveils a microbe-encoded enzymatic process that contributes to enhanced athletic performance.
Genomic loci susceptible to systematic sequencing bias in clinical whole genomes
Background: Highly accurate next-generation sequencing (NGS) of genetic variants is key to many areas of science and medicine, such as cataloguing population genetic variation and diagnosing patients with genetic diseases. Certain genomic loci and...
Storytelling Helps Hospital Staff Learn About The Person, Not Just The Patient
VA hospitals are pioneering the use of storytelling to strengthen the relationships patients have with doctors and nurses. With more information about patients, there may be some health benefits.
The somatic mutation landscape of the human body
Somatic mutations in healthy tissues contribute to aging, neurodegeneration, and cancer initiation, yet remain largely uncharacterized. To gain a better understanding of their distribution and functional impacts, we leveraged the genomic information...
N.I.H. Head Calls for End to All-Male Panels of Scientists
Francis Collins pledged to decline to speak at conferences that do not include enough women in prominent speaking roles.
I Needed to Save My Mother’s Memories. I Hacked Her Phone.
After she died, breaking into her phone was the only way to put together the pieces of her digital life.
Gene 'revolution' in sick children diagnosis
From next year, all seriously ill children in England can have their DNA analysed to help get a diagnosis.
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euan ashley
All seriously ill children in England with an unexplained disorder will be eligible for genome analysis from next year.
41d
Extreme events reveal an alimentary limit on sustained maximal human energy expenditure
The limits on maximum sustained energy expenditure are unclear but are of interest because they constrain reproduction, thermoregulation, and physical activity. Here, we show that sustained expenditure in humans, measured as maximum sustained...
Physical limit of human endurance related to food, not temperature, study shows
‘This defines the realm of what’s possible for humans, there’s just a limit to how many calories our guts can effectively absorb per day’
RNA velocity and protein acceleration from single-cell multiomics experiments
The simultaneous quantification of protein and RNA makes possible the inference of past, present and future cell states from single experimental snapshots. To enable such temporal analysis from multimodal single-cell experiments, we introduce an...