The field of hematopoietic cell transplantation (HCT) is characterized by substantial
practice variations in therapeutic approaches including preferred donor, graft source,
conditioning regimens and graft-versus-host disease (GVHD) prophylaxis. Many...
Florent MalardHematopoietic Cell Transplantation: Practice predictions for the Year 2023 - Biology of Blood and Marrow Transplantation
A new bispecific CAR T cell product targeting the CD20 and CD19 antigens demonstrates an excellent safety profile and high clinical efficacy in patients with B cell non-Hodgkin lymphoma and chronic lymphocytic leukemia.
Florent MalardBispecific anti-CD20, anti-CD19 CAR T cells for relapsed B cell malignancies: a phase 1 dose escalation and expansion trial | Nature Medicine
This systematic review and meta-analysis assesses the association of the addition of daratumumab to backbone multiple myeloma regimens with progression-free survival among patients with cytogenetically defined high-risk multiple myeloma.
The role of hematopoietic cell transplantation (HCT) in the management of newly diagnosed
adult acute myeloid leukemia (AML) is reviewed and critically evaluated in this evidence-based
review. An AML expert panel, consistent of both transplant and...
This cohort study evaluates the incidence of nosocomial coronavirus disease 2019 (COVID-19) among patients admitted to a US medical center in the context of a comprehensive and progressive infection control program.
The SARS-Cov-2 pandemic significantly impacted on oncology practice across the globe. There is uncertainty as to the contribution of patients' demographics and oncological features on severity and mortality from Covid-19 and little guidance as to...
Florent MalardClinical portrait of the SARS-CoV-2 epidemic in European cancer patients. | Cancer Discovery #covid-19
The GvHD Hub are proud to present expert interviews directly from the 61st American Society of Hematology (ASH) meeting in Orlando, US. This interview with Florent Malard, Saint-Antoine Hospital, Paris, FR, was based on the question: Is the...
This study adds to the evidence that patients with haematological malignancies have
worse outcomes than both the general population with COVID-19 and patients with haematological
malignancies without COVID-19. The high mortality among patients with...
Florent MalardClinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study
This systematic review investigates whether published data support the safety and effectiveness of microtransplantation of hematopoietic cells in persons with acute myeloid leukemia and myelodysplastic syndrome.
Florent MalardMicrotransplantation for Acute Myeloid Leukemia: A Systematic Review | Stem Cell Transplantation | JAMA Oncology #amlsm
Psychological stress has adverse effects on various human diseases, but the mechanisms
by which stress influences disease activity remain unclear. Xu et al. discover that
the influence of psychological stress vaso-occlusion in sickle cell disease...
Florent MalardThe Gut Microbiome Regulates Psychological-Stress-Induced Inflammation: Immunity #microbiota