Henrik Salje
Infectious disease epidemiologist at the University of Cambridge
Thought Leader
| #33 | Infectious Disease |
Last synced from Twitter 3h ago
Serological signatures of SARS-CoV-2 infection: Implications for antibody-based diagnostics
Background Infection with SARS-CoV-2 induces an antibody response targeting multiple antigens that changes over time. This complexity presents challenges and opportunities for serological diagnostics. Methods A multiplex serological assay was...
Probability of symptoms and critical disease after SARS-CoV-2 infection
We quantified the probability of developing symptoms (respiratory or
fever>=37.5 °C) and critical disease (requiring intensive care or
resulting in death) of SARS-CoV-2 positive subjects. 4,326 contacts of
SARS-CoV-2 index cases detected in...
Coronavirus protective immunity is short-lasting
In the current COVID-19 pandemic a key unsolved question is the duration of acquired immunity in recovered individuals. The recent emergence of SARS-CoV-2 precludes a direct study on this virus, but the four seasonal human coronaviruses may reveal...
Seroepidemiologic Study Designs for Determining SARS-COV-2 Transmission and Immunity
Serologic studies are crucial for clarifying dynamics of the coronavirus disease pandemic. Past work on serologic studies (e.g., during influenza pand...
How deadly is the coronavirus? Scientists are close to an answer
Public-health researchers use the infection fatality rate to gauge how to respond to a new disease, but it’s tricky to calculate.
Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study
These results suggest that most of the population of Geneva remained uninfected during
this wave of the pandemic, despite the high prevalence of COVID-19 in the region (5000
reported clinical cases over <2·5 months in the population of half a...
Reconstructing Mayaro virus circulation in French Guiana shows frequent spillovers
Mayaro virus (MAYV) is an emerging arbovirus, but cross-reactivity with other alphaviruses makes analysis of its epidemiology difficult. Here, the authors develop an analytical framework to assess MAYV epidemiology and find evidence for an important...
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Henrik Salje
Using Mayaro and chikungunya viruses in French Guiana as an example, we show analyzing serological data from related viruses simultaneously allows us to better characterize spread than when pathogens are considered separately. @Nathoze @SCauchemez nature.com/articles/s4146… pic.twitter.com/M2qVwYyd9J
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Changing Contact Patterns Over Disease Progression: Nipah Virus as a Case Study
We examined whether contact patterns change as disease progresses. For Nipah virus case patients identified between 2010 and 2014 in Bangladesh, the number of c
Serology for SARS-CoV-2: Apprehensions, opportunities, and the path forward
Serological testing for SARS-CoV-2 has enormous potential to contribute to COVID-19 pandemic response efforts. However, the required performance characteristics of antibody tests will critically depend on the use case (individual-level vs....
Estimating the burden of SARS-CoV-2 in France
France has been heavily affected by the SARS-CoV-2 epidemic and went into lockdown on the 17 March 2020. Using models applied to hospital and death data, we estimate the impact of the lockdown and current population immunity. We find 3.6% of...
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Henrik Salje
Despite 20,000+ COVID19 deaths, we find only ~5% of France infected. The lockdown, eased on Monday, reduced transmission by 80%, however R still close to 1 (~0.7) with 3-6k daily infections, leaving little room for post-lockdown increases @ScienceMagazine bit.ly/2zzLKJX pic.twitter.com/IaeVeHYiDn
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Serological signatures of SARS-CoV-2 infection: Implications for antibody-based diagnostics
Background
The antibody response generated following infection with SARS-CoV-2 is expected to decline over time. This may cause individuals with confirmed SARS-CoV-2 infection to test negative according to serological diagnostic tests in the months...
SARS-CoV-2 serological analysis of COVID-19 hospitalized patients, pauci-symptomatic individuals and blood donors.
It is of paramount importance to evaluate the prevalence of both asymptomatic and symptomatic cases of SARS-CoV-2 infection and their antibody response profile. Here, we performed a pilot study to assess the levels of anti-SARS-CoV-2 antibodies in...
A systematic review of antibody mediated immunity to coronaviruses: antibody kinetics, correlates of protection, and association of antibody responses with severity of disease
The duration and nature of immunity generated in response to SARS-CoV-2 infection is unknown. Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that...
Opportunities for improved surveillance and control of dengue from age-specific case data
Age-specific incidence data, combined with mechanistic models of immunity, provides a unique opportunity to characterize disease transmission of dengue and other immunizing diseases at high temporal and spatial resolution.
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Henrik Salje
Age data of cases are simple to collect, are (largely) robust to surveillance bias and quantify infection risk much better than case counting. Illustration with dengue. @isabelrodbar @datcummings @eLife elifesciences.org/articles/45474 pic.twitter.com/wejALSEr4S
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Transmission of Nipah Virus — 14 Years of Investigations in Bangladesh | NEJM
Original Article from The New England Journal of Medicine — Transmission of Nipah Virus — 14 Years of Investigations in Bangladesh
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Henrik Salje
Long-term dedicated surveillance needed to understand emergent pathogens. Our study of human Nipah transmission over past 14y identifies key role of fluid exposures and likely no asymptomatic infection. @NEJM @icddr_b @binikolay @SCauchemez EmilyGurley nejm.org/doi/full/10.10… pic.twitter.com/pyx3gA0QBa
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