Henrik Salje
Infectious disease epidemiologist at the University of Cambridge
Thought Leader
#35 Infectious Disease
Last synced from Twitter 81d ago
Postdoc in mathematical/statistical modelling of the COVID-19 pandemic • Research
Research 154d 4 tweets
Postdoctoral position in mathematical/statistical modelling of the COVID-19 pandemic at Institut Pasteur, Paris
Serological signatures of SARS-CoV-2 infection: Implications for antibody-based diagnostics
medRxiv 201d 2 tweets
Background Infection with SARS-CoV-2 induces an antibody response targeting multiple antigens that changes over time. This complexity presents challenges and opportunities for serological diagnostics. Methods A multiplex serological assay was...
Probability of symptoms and critical disease after SARS-CoV-2 infection
arXiv.org 214d 2 tweets
We quantified the probability of developing symptoms (respiratory or fever>=37.5 °C) and critical disease (requiring intensive care or resulting in death) of SARS-CoV-2 positive subjects. 4,326 contacts of SARS-CoV-2 index cases detected in...
Coronavirus protective immunity is short-lasting
medRxiv 213d 5 tweets
In the current COVID-19 pandemic a key unsolved question is the duration of acquired immunity in recovered individuals. The recent emergence of SARS-CoV-2 precludes a direct study on this virus, but the four seasonal human coronaviruses may reveal...
Seroepidemiologic Study Designs for Determining SARS-COV-2 Transmission and Immunity
Emerging Infectious Diseases journal 214d 2 tweets
Serologic studies are crucial for clarifying dynamics of the coronavirus disease pandemic. Past work on serologic studies (e.g., during influenza pand...
How deadly is the coronavirus? Scientists are close to an answer
Nature.com 215d 22 tweets
Public-health researchers use the infection fatality rate to gauge how to respond to a new disease, but it’s tricky to calculate.
Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study
The Lancet 219d 17 tweets
These results suggest that most of the population of Geneva remained uninfected during this wave of the pandemic, despite the high prevalence of COVID-19 in the region (5000 reported clinical cases over <2·5 months in the population of half a...
Reconstructing Mayaro virus circulation in French Guiana shows frequent spillovers
Nature Communications 224d 1 tweets
Mayaro virus (MAYV) is an emerging arbovirus, but cross-reactivity with other alphaviruses makes analysis of its epidemiology difficult. Here, the authors develop an analytical framework to assess MAYV epidemiology and find evidence for an important...
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Henrik Salje Using Mayaro and chikungunya viruses in French Guiana as an example, we show analyzing serological data from related viruses simultaneously allows us to better characterize spread than when pathogens are considered separately. 224d
Title not found
Osf.io 231d 4 tweets
Is SARS-CoV-2 viral load lower in young children than adults?
David Spiegelhalter - Medium 236d 8 tweets
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Implications of the Age Profile of the Novel Coronavirus
Dash.harvard.edu 296d 2 tweets
Changing Contact Patterns Over Disease Progression: Nipah Virus as a Case Study
OUP Academic 320d 2 tweets
We examined whether contact patterns change as disease progresses. For Nipah virus case patients identified between 2010 and 2014 in Bangladesh, the number of c
Serology for SARS-CoV-2: Apprehensions, opportunities, and the path forward
Science Immunology 243d 10 tweets
Serological testing for SARS-CoV-2 has enormous potential to contribute to COVID-19 pandemic response efforts. However, the required performance characteristics of antibody tests will critically depend on the use case (individual-level vs....
Estimating the burden of SARS-CoV-2 in France
Science 249d 42 tweets
France has been heavily affected by the SARS-CoV-2 epidemic and went into lockdown on the 17 March 2020. Using models applied to hospital and death data, we estimate the impact of the lockdown and current population immunity. We find 3.6% of...
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Henrik Salje Despite 20,000+ COVID19 deaths, we find only ~5% of France infected. The lockdown, eased on Monday, reduced transmission by 80%, however R still close to 1 (~0.7) with 3-6k daily infections, leaving little room for post-lockdown increases 249d
Serological signatures of SARS-CoV-2 infection: Implications for antibody-based diagnostics
Hal-pasteur.archives-ouvertes.fr 251d 1 tweets
Background The antibody response generated following infection with SARS-CoV-2 is expected to decline over time. This may cause individuals with confirmed SARS-CoV-2 infection to test negative according to serological diagnostic tests in the months...
SARS-CoV-2 serological analysis of COVID-19 hospitalized patients, pauci-symptomatic individuals and blood donors.
medRxiv 267d 4 tweets
It is of paramount importance to evaluate the prevalence of both asymptomatic and symptomatic cases of SARS-CoV-2 infection and their antibody response profile. Here, we performed a pilot study to assess the levels of anti-SARS-CoV-2 antibodies in...
A systematic review of antibody mediated immunity to coronaviruses: antibody kinetics, correlates of protection, and association of antibody responses with severity of disease
medRxiv 267d 5 tweets
The duration and nature of immunity generated in response to SARS-CoV-2 infection is unknown. Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that...
Opportunities for improved surveillance and control of dengue from age-specific case data
eLife 580d 1 tweets
Age-specific incidence data, combined with mechanistic models of immunity, provides a unique opportunity to characterize disease transmission of dengue and other immunizing diseases at high temporal and spatial resolution.
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Henrik Salje Age data of cases are simple to collect, are (largely) robust to surveillance bias and quantify infection risk much better than case counting. Illustration with dengue. 580d
Transmission of Nipah Virus — 14 Years of Investigations in Bangladesh | NEJM
New England Journal of Medicine 620d 7 tweets
Original Article from The New England Journal of Medicine — Transmission of Nipah Virus — 14 Years of Investigations in Bangladesh
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Henrik Salje Long-term dedicated surveillance needed to understand emergent pathogens. Our study of human Nipah transmission over past 14y identifies key role of fluid exposures and likely no asymptomatic infection. EmilyGurley 619d