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What do Americans really think about climate change?
Climate Insights 2020 assessed 27,661 people across different States, to explore what Americans really think about climate change
Universities forcing publishers to the negotiating table over freeing academic content from paywalls
Universities are forcing publishers to the negotiating table over freeing academic content from paywalls
SMAR1 repression by pluripotency factors and consequent chemoresistance in breast cancer stem-like cells is reversed by aspirin
Cancer stem cells (CSCs) are tumor cells with stem cell-like qualities that promote tumor progression, adaption to stress, and resistance to chemotherapy. Bhattacharya et al . found that aspirin targets CSCs in a way that may enhance the efficacy of...
Nature journals announce first open-access agreement
The arrangement will allow some researchers in Germany to publish openly — but critics say it comes with a high price.
Phase I Study of Lysine-Specific Demethylase-1 Inhibitor CC-90011 in Patients With Advanced Solid Tumors and Relapsed/Refractory Non-Hodgkin Lymphoma
PURPOSE: Lysine-specific demethylase 1 (LSD1) is implicated in multiple tumor types and its expression in cancer stem cells is associated with chemoresistance. CC-90011 is a potent, selective, and reversible oral LSD1 inhibitor. We examined CC-90011...
Powerful US research funder unveils strict open-access policy
The Howard Hughes Medical Institute is the second major US funder to mandate that the research it pays for must be free to read on publication.
Evaluating Review Commons – the first 9 months
In late 2019, EMBO and ASAPbio launched Review Commons, a platform for journal-independent peer review that facilitates the posting of a refereed preprint and submission to 17 partner journals. With this system, we aimed to improve peer review in...
Preprint Review: A guide for authors
Preprint Review is a first step by eLife towards a system that combines author-driven publication (via preprint) with robust and reliable peer review.
Hunting down the dominating subclone of cancer stem cells as a potential new therapeutic target in multiple myeloma: An artificial intelligence perspective
Hunting down the dominating subclone of cancer stem cells as a potential new therapeutic target in multiple myeloma: An artificial intelligence perspective
SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells
Cancer stem cells can evade treatment. Here, the authors perform an in vitro screen to identify proteins that are involved in protecting glioma cancer stem cells from therapy and find that SPT6 increases BRCA1 expression and drives error-free DNA...
Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas
Adenosquamous cancer of the pancreas (ASCP) is a subtype of pancreatic cancer that has a worse prognosis and greater metastatic potential than the more common pancreatic ductal adenocarcinoma (PDAC) subtype. To distinguish the genomic landscape of...
Demand Change for Long-Term Care | Care Not Profits
DEMAND CHANGE FOR LONG-TERM CARE! Send a letter to Premier Ford demanding urgent actions that protect our most vulnerable loved ones.
Canada Post set recognizes modern medical innovators
The designs show six of the country’s cutting-edge physicians and researchers.
Safeguard Science Advice in Canada
Jim Till
I signed @E4Dca open letter calling on @JustinTrudeau @NavdeepSBains @cafreeland to safeguard science advice by securing the @ChiefSciCan through legislation & expanding its mandate & budget. Science advice is critical to our democracy. Add your name
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Jim Till
.@JustinTrudeau @NavdeepSBains @cafreeland The term of @ChiefSciCan ends Thursday. We are facing challenges that demand a science-based response. Will you take immediate action to safeguard science advice?
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Springer Nature’s Transformative Agreements enable country level transition to open access | Corporate Affairs Homepage | Springer Nature
New data demonstrates that Springer Nature’s national transformative agreements can drive the open access (OA) transition, significantly increase
Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer
The unraveling of distinct mammary tumor hierarchies in various mouse models of breast cancer emphasizes the need to account for specific cell states with potentially varying therapeutic vulnerabilities in tumors.
Advances in Therapeutic Targeting of Cancer Stem Cells within the Tumor Microenvironment: An Updated Review
Despite great strides being achieved in improving cancer patients’ outcomes through better therapies and combinatorial treatment, several hurdles still remain due to therapy resistance, cancer recurrence and metastasis. Drug resistance culminating...
Photothermogenetic inhibition of cancer stemness by near-infrared-light-activatable nanocomplexes
Cancer stem cells (CSCs) are known to induce chemotherapy resistance, and cause tumour relapse and metastasis. Here, the authors develop photoactive nanocarbon complexes with second near-infrared photothermal ability to target cancer cells...
Jim Till
Photothermogenetic inhibition of cancer stemness by near-infrared-light-activatable nanocomplexes ift.tt/3iLAf3g #cancerSC via @MBiofund
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