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Technical and social issues influencing the adoption of preprints in the life sciences
Preprints are gaining visibility in many fields. Thanks to the explosion of bioRxiv, an online server for preprints in biology, versions of manuscripts prior to the completion of journal-organized peer review are poised to become a standard...
Open-access megajournals lose momentum as the publishing model matures
Concerns include declining volume, slower publication, and softening citation measures
New Product Roadmap: How we're supporting journals in the transition to Plan S and sustainable OA
Scholastica announces the release of a Product Roadmap detailing new features to help journals comply with Plan S and sustainably meet core technical publishing standards.
A genome‐wide RNAi screen reveals essential therapeutic targets of breast cancer stem cells | EMBO Molecular Medicine
The development of cancer stem cell‐targeting therapies is of major interest and requires insight into the underlying mechanisms. In this study, a genome‐wide RNAi screen was established, and reveale...
TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment
TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment
Targeting oxidative pentose phosphate pathway prevents recurrence in mutant Kras colorectal carcinomas
This study shows that CDCP1-positive cancer stem cells represent a critical driving force behind tumor relapse in colorectal tumors that have mutant Kras and reveals a unique role for the oxidative pentose phosphate pathway in this process.
Pheno-seq – linking visual features and gene expression in 3D cell culture systems
Pheno-seq – linking visual features and gene expression in 3D cell culture systems
Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy
The generation of biomimetic nanoparticles that retain the integrity of proteins has been a challenge. Here, the authors generate biomimetic nanoparticles that are exocytosed from tumour cells and show their therapeutic potential in targeting...
Jim Till
Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy nature.com/articles/s4146… #cancerSC via @Santos_Lab15
24d
Judge finds written attack on climate scientist too ludicrous to be libel
Canadian court dismisses suit by climate scientist turned elected official.
ADAMDEC1 maintains a growth factor signaling loop in cancer stem cells
Glioblastomas (GBM) are lethal brain tumors where poor outcome is attributed to cellular heterogeneity, therapeutic resistance, and a highly infiltrative nature. These characteristics are preferentially linked to GBM cancer stem cells (GSCs), but...
Collaboration without Elsevier is the key to open access and open science
This morning, Times Higher Education published a strange and awkward piece from a representative of Elsevier. If you have a subscription you can view it online here. Unsurprisingly for Elsevier though, it contained a number of misleading statements....
Using Europe PMC RESTful APIs
What is FAIR-biomed? FAIR-biomed is a browser extension that aims to facilitate investigative research in biomedicine. It connects user...
Discrepancy in scientific authority and media visibility of climate change scientists and contrarians
The role of climate change (CC) contrarians is neglected in climate change communication studies. Here the authors used a data-driven approach to identify CC contrarians and CC scientists and found that CC scientists have much higher citation impact...
Vote Science
Vote Science Campaign. Advocating for Science in the Canadian Federal Election.
Jim Till
How to #VoteScience in the upcoming federal election. It's a way to send a message that Canadians care about science and evidence. You can email the candidates in your riding.
33d
Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression
Cancer cells can use autophagy as a mechanism of surviving from external stresses. Here, the authors show that Pfkfb3, a glycolytic gene, is expressed in metastatic breast cancer cells but not in dormant cells that demonstrate features of autophagy.
Two New Initiatives at eLife To Start the Eisen Era
Michael Eisen's bold visions for eLife emerge on Twitter. We consider two of his proposed initiatives.
In departure for NIH, Cancer Moonshot requires grantees to make papers immediately free
Open-access requirement diverges from usual U.S. government policy
A New Clue to How Life Originated
A long-standing mystery about early cells has a solution—and it’s a rather magical one.