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Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies
A method for the multimodal volumetric imaging of RNAs and proteins in intact tumour volumes and organoids enables the spatial transcriptional profiling of coding RNAs and non-coding RNAs at single-cell resolution in cancer tissues.
The relationship between bioRxiv preprints, citations and altmetrics
The relationship between bioRxiv preprints, citations and altmetrics
Rapid publications risk the integrity of science in the era of COVID-19
Preprint manuscripts, rapid publications and opinion pieces have been essential in permitting the lay press and public health authorities to preview data relating to coronavirus disease 2019 (COVID-19), including the range of clinical manifestations...
Top Notch Targeting Strategies in Cancer: A Detailed Overview of Recent Insights and Current Perspectives
Evolutionarily conserved Notch plays a critical role in embryonic development and cellular self-renewal. It has both tumour suppressor and oncogenic activity, the latter of which is widely described. Notch-activating mutations are associated with...
Jim Till
Top Notch Targeting Strategies in Cancer: A Detailed Overview of Recent Insights and Current Perspectives [review] mdpi.com/2073-4409/9/6/… #cancerSC via @steph_annett
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Effect of Dexamethasone in Hospitalized Patients with COVID-19: Preliminary Report
Background: Coronavirus disease 2019 (COVID-19) is associated with diffuse lung damage. Corticosteroids may modulate immune-mediated lung injury and reducing progression to respiratory failure and death. Methods: The Randomised Evaluation of...
Preprints on PMC and PubMed: an interview with NLM’s Kathryn Funk
On the topic of preprints, “how do I find them?” remains one of the most common questions. While several search tools already index preprints, many require researchers to look outside of their normal workflows. On June 9, the National Library of...
Huge open-access journal deal inked by University of California and Springer Nature
Pact could ultimately make articles in Nature journals immediately free to read
Universities Step Up the Fight for Open-Access Research
Today’s deal between the University of California and publisher Springer Nature is a big milestone on the path to dismantling paywalls around academic journals.
Is Peer Review a Good Idea?
Abstract. Prepublication peer review should be abolished. We consider the effects that such a change will have on the social structure of science, paying parti
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion
Su et al. develop two potent small-molecule inhibitors against an RNA N6-methyladenosine
demethylase called FTO. FTO inhibition shows anti-tumor effects in several types of
cancers in mouse models by restricting self-renewal of cancer stem cells and...
After Taming Open Access, Academic Publishing Giants Now Seek To Assimilate The World Of Preprints
As Techdirt has reported, the open access movement seeks to obtain free access to research, particularly when it is funded by taxpayers' money. Naturally, traditional academic publishers enjoying profit margins of 30 to 40% are fighting to hold...
ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity
The ubiquitin-like modifier ISG15 exerts post-translational protein regulation through ISGylation. Here, the authors show that ISGylation is necessary for pancreatic cancer stem cell self-renewal and tumourigenesis by supporting the recycling of...
Europe PMC
Europe PMC is an archive of life sciences journal literature.
Jim Till
Onward to new endeavours, Mary!Do you remember being a co--author on this publication?
"An approach to classifying prognostic factors related to survival experience for non-Hodgkin's lymphoma patients: based on a series of 982 patients: 1967-1975."
36d
The acceptability of using a lottery to allocate research funding: a survey of applicants
The Health Research Council of New Zealand is the first major government funding agency to use a lottery to allocate research funding for their Explorer Grant scheme. This is a somewhat controversial approach because, despite the documented problems...
Reasons to Worry Less About the Explosion of Preprints - Absolutely Maybe
It looks as though preprints are here to stay in biomedicine, and I think that’s great. But I’ve been hearing variants of…
Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors
Cancer stem cells that reside in a protective niche are considered the culprit in
therapy failure and relapse in most patients. Rothe et al. identified a targetable
vulnerability within focal adhesions of leukemic stem cells that can resensitize...
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia
Selectively eradicating cancer stem cells in acute myeloid leukemia (AML) remains
a challenge. Shen et al. demonstrate that targeting ALKBH5, an m6A eraser, effectively
inhibits AML development/maintenance and suppresses leukemia stem cell...
Jim Till
#cancerSC [$]
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia
52d
New from eLife: Invitation to submit to Preprint Review
Authors can now request peer review without being evaluated for publication in eLife up front.
The Glioma Stem Cell Model in the Era of Single-Cell Genomics
Glioma stem cells (GSCs) are thought to underlie glioma initiation, evolution, and
resistance to existing therapies. Although functional evidence for GSCs is abundant,
tumor heterogeneity and intrinsic limitations in GSC assays have represented...