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Motivation: Next-generation sequencing has become an important tool for genome-wide quantification of DNA and RNA. However, a major technical hurdle lies in the need to map short sequence reads back to their correct locations in a reference genome....
J.J. EmersonAnother thing we've known forever is that there is a mapping bias that creeps in in when only a single reference genome is in allele specific expression (e.g. ncbi.nlm.nih.gov/pmc/articles/P…). To combat this, Xinwen sequenced & assembled both strains with long reads. 6/10
Gene expression variation between alleles in a diploid cell is mediated by variation in cis regulatory sequences, which usually refers to the differences in DNA sequence between two alleles near the gene of interest. Expression differences caused by...
J.J. EmersonI'm very excited to Xinwen Zhang's first preprint posted on @biorxivpreprint: "Inferring the genetic architecture of expression variation from replicated high throughput allele-specific expression experiments" 1/10