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Pentagon Concerned Russia Cultivating Sympathy Among US Troops
Russian efforts to weaken the West through a relentless campaign of information warfare may be starting to pay off, cracking a key bastion of the U.S. line of defense: the military.
While most Americans still see Moscow as a key U.S.
Join the Seattle Flu Study!
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Ancient Rome: A genetic crossroads of Europe and the Mediterranean
Rome wasn't built (or settled) in a day. Antonio et al. performed an ancestral DNA analysis to investigate the genetic changes that occurred in Rome and central Italy from the Mesolithic into modern times. By examining 127 Roman genomes and their...
A computational challenge to help developmental biology
Q&A with the scientists and organizers behind a new competition to use machine learning to reconstruct an entire animal’s developmental lineage
Allen Frontiers Symposium 2019
Jay Shendure
Looking forward to the @AllenFrontiers Symposium on Oct 16-17 in Boston (HMS-Longwood). These are consistently fantastic meetings!
tinyurl.com/y5ncm2y4 pic.twitter.com/o41Xn7we6u
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Synapse | Sage Bionetworks
Synapse is a platform for supporting scientific collaborations centered around shared biomedical data sets. Our goal is to make biomedical research more transparent, more reproducible, and more accessible to a broader audience of scientists. ...
India's 1st Illegal Immigrant Detention Camp Size Of 7 Football Fields
About 150 kilometre west of Guwahati, construction is on in full swing to build India's first detention centre for those declared foreigners after the publication of the contentious Assam National Register of Citizens or NRC last month.
Brotman Baty Institute on LinkedIn: "Join the BBI Team! BBI has several open positions: LEAD COMPUTATIONAL BIOLOGIST FOR OUR SINGLE CELL INITIATIVE- https://bit.ly/2jXECiS RESEARCH SCIENTIST ENGINEER 1- https://lnkd.in/gQN_dRv RESEARCH SCIENTIST 2- http
September 10, 2019: Brotman Baty Institute posted an article on LinkedIn
Jay Shendure
Multiple experimental & computational positions related to single cell genomics & multiplex genome editing open at the @BrotmanBaty Institute -- if you are in Seattle (or want to be in Seattle) and this might be a fit, please taking a look!
linkedin.com/feed/update/ur… pic.twitter.com/0LDcdjTNnV
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UW Human Resources
University of Washington Human Resources
Single cell ATAC-seq in human pancreatic islets and deep learning upscaling of rare cells reveals cell-specific type 2 diabetes regulatory signatures
Type 2 diabetes (T2D) is a complex disease characterized by pancreatic islet dysfunction, insulin resistance, and disruption of blood-glucose levels. Genome-wide association studies (GWAS) have identified >400 independent signals that encode genetic...
A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell resolution
Caenorhabditis elegans is an animal with few cells, but a striking diversity of cell types. Here, we characterize the molecular basis for their specification by profiling the transcriptomes of 86,024 single embryonic cells. We identify 502 terminal...
Jay Shendure
This paper from @jspacker is just hands down amazing.
science.sciencemag.org/content/early/… pic.twitter.com/vb9WXi2sKx
95d
High-Throughput Single-Cell Sequencing with Linear Amplification
Yin et al. developed sci-L3, which combines a scalable single-cell barcoding scheme
with linear amplification. The method flexibly enables single-cell whole-genome sequencing,
targeted DNA sequencing, or concurrent profiling of the genome and...
Jay Shendure
Our latest, by the brilliant @yeastyin, is sci-L3, a scalable and flexible method for single cell WGS, single cell targeted DNA-seq, or single cell RNA/DNA co-assays. Linear amplification + 3-level combinatorial indexing.
cell.com/molecular-cell… pic.twitter.com/TxjcnIXYqj
96d
Brotman Baty Institute on LinkedIn: "Join the #BBI Team! BBI has several open positions: RESEARCH SCIENTIST ENGINEER 1- https://lnkd.in/gQN_dRv RESEARCH SCIENTIST 2- https://lnkd.in/gsEpVQy RESEARCH SCIENTIST ENGINEER 4- https://lnkd.in/gtni3_q MUTATI
August 15, 2019: Brotman Baty Institute posted an article on LinkedIn
Saturation mutagenesis of twenty disease-associated regulatory elements at single base-pair resolution
Interpreting genetic variation in the noncoding genome remains challenging, with functional effects difficult to predict. Here, the authors perform saturation mutagenesis combined with massively parallel reporter assays for 20 disease-associated...
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Jay Shendure
Our work w/ @NadavAhituv and Kircher labs, MPRA saturation mutagenesis of 20 disease-associated regulatory elements (30K variant effect measurements) out in @NatureComms. Work superbly led by Martin Kircher, Chenling Xiong, @bethkarenmartin & Max Schubach!
125d
In Situ Transcriptome Accessibility Sequencing (INSTA-seq)
Subcellular RNA localization regulates spatially polarized cellular processes, but unbiased investigation of its control in vivo remains challenging. Current hybridization-based methods cannot differentiate small regulatory variants, while in situ...
1
Jay Shendure
Incredibly cool and creative paper from @jlee8usa at @CSHL. Opens the door to in situ full-length (!) mRNA sequencing as well as high-res in situ mapping of RNA protein interactions.
127d
Concurrent Genome and Epigenome Editing by CRISPR-Mediated Sequence Replacement
Recent advances in genome editing have facilitated the direct manipulation of not only the genome, but also the epigenome. Genome editing is typically performed by introducing a single CRISPR/Cas9-mediated double stranded break (DSB), followed by...
1
Jay Shendure
Our latest preprint, work by Jes Alexander, describes concurrent genome and epigenome editing by NHEJ mediated sequence replacement; results support view that promoter methylation sufficient to functionally silence gene expression
175d
Characterizing the temporal dynamics of gene expression in single cells with sci-fate
Gene expression is a dynamic process on multiple scales, e.g. the cell cycle, response to stimuli, normal differentiation and development, etc. However, nearly all techniques for profiling gene expression in single cells fail to directly capture...
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Jay Shendure
There is no fate but what we make for ourselves, in the form of newly synthesized RNA. Our latest preprint describes sci-fate, new method by @junyue_cao that combines single cell combinatorial indexing and 4SU labeling
183d