BMJ is a values-driven company operating at the nexus of where digital technology meets the latest knowledge and opinion to inform medical decision-making.
Joseph RossCalling all clever, purpose-driven, patient-centered, rigorous clinical researchers, esp women & URM, @bmj_latest is looking for a freelance editor. Years of journal experience NOT necessary. Reach out to me, @drhelmac or @eloder if interested.
Background NVX-CoV2373 is a recombinant nanoparticle vaccine composed of trimeric full-length SARS-CoV-2 spike glycoproteins. We present the Day 35 primary analysis of our trial of NVX-CoV2373 with or without the saponin-based Matrix-M1 adjuvant in...
Joseph RossDelighted to see that Novavax's Tuesday afternoon press release on its vaccine trial was followed 2 days later by posting of the trial report as a preprint. Good for science, good for public and scientific scrutiny.
To defeat the virus, we will have to start thinking in years, not months.
Joseph RossTerrific piece by @HowardMarkel on history and current use of the "nuclear option": physical/social distancing. A quiet form of civic action that has saved millions of lives. But distancing cannot cure or defeat #COVID19, it only allows us to hide from it
Randy Schekman is getting a bit tired of talking about this.
But then, this could be the last time he has to.
“The argument for open access is so obvious, it’s painful to have to repeat it,” says Schekman, a 2013 Nobel laureate and UC Berkeley...
Joseph RossScience, uninterrupted: Will COVID-19 mark the end of scientific publishing as we know it?
Back in the 1960s and 70s, in the city of Pittsburgh, there was a nickname for guys like John Moon – The Unemployables. This nickname meant that you simply could not get hired, no matter where you went for a job. Moon grew up in Pittsburgh’s largely...
Joseph RossICYMI, fascinating story of Freedom House ambulance service in Pittsburgh, launching the field of paramedicine. All too common in healthcare: individuals striving to make their communities stronger and healthier, done in by hierarchy and structural racism
Dr. Sapan Desai, who supplied the data for two prominent and later retracted studies, is said to have a history of cutting corners and misrepresenting information in pursuit of his ambitions.
Joseph RossSo many worrying details in this story of Dr. Desai and Surgisphere. But this bit is absolutely laughable, and shows how unlikely it is that the data were even real. "Few people were needed ... hospitals could easily ... without technical assistance." nytimes.com/2020/07/27/sci…pic.twitter.com/6YVdUon7BT
Joseph RossFDA released interim results from the postmarket surveillance study of #Essure today, further justifying so many women's reporting of complications over the objections of the company. First, it "works" less often than tubal ligation: 94.6% vs. 99.6% (1/3)
The wave of buybacks has juiced earnings, but ignored high prices.
Joseph RossICYMI bc of #COVID19, 12 of the largest Pharma companies spent $183B on stock buybacks from 2016-2019, versus $251B on R&D. Amgen and Biogen spent more! Something to remember when Pharma pleads high drugs prices are needed for R&D investment @bobjherman
How does mortality differ across countries? Examining the number of deaths per confirmed case and per 100,000 population. A global comparison.
Joseph RossAnd @CDCDirector's quote is worrisome, saying that infections in younger folks are ok. Sweden protected older adults at risk, allowed young to mingle freely. Thus far, Sweden has experienced 51 deaths/100k from COVID, near Italy and Spain (57 and 60)
WASHINGTON (AP) — How accurate are the coronavirus tests used in the U.S.?
Months into the outbreak, no one really knows how well many of the screening tests work, and experts at top...
Joseph RossWe need better data, and we need higher regulatory standards, so that the sensitivity and specificity of the COVID19 antigen and antibody tests are determined and made clear. Otherwise, public health has one hand tied behind its back. HT @thackerpd
Joseph RossFor those looking to stay on top of COVID19 research, check out @CSPI's Evidence Hub, aggregating websites that list ongoing and completed COVID19 studies, study results, and study appraisals in one place. Nice work by @DrPeterLurie and team.
Mass demonstrations in all fifty states have upended reopening timetables and altered the meaning of the antiviral fight.
Joseph RossAnother must read @DhruvKhullar: "I find myself returning to the words “I can’t breathe.” Eric Garner and George Floyd said them; they’re also uttered each day by many [hospitalized] COVID-19 patients—a disproportionate number of whom are people of color"
This Viewpoint uses publicly available data to analyze the number of deaths from seasonal influenza deaths compared with deaths from coronavirus disease 2019.
Joseph RossGreat piece in @JAMAInternalMed making sense of what is being seen clinically in hospitals & ICUs, explaining why one can't compare actual COVID19 fatality counts & CDC's estimated seasonal influenza deaths, suggesting COVID mortality risk is 10-45x higher
Joseph RossFascinating analysis by @aleszubajak & @crowdsourcing of ~900 #COVID19 preprints reveals two internets, one largely ideological, in which science is leveraged as propaganda, and one that consists of vital discussion and debate needed in science & democracy
Two weeks after the dislosure of data on Gilead's remdesivir, the public still hasn't seen full results, leaving others without critical insights.
Joseph RossMy recommendation to avoid this situation going forward, since history is bound to repeat itself. "Before the FDA issues an emergency [use] authorization for a Covid-19 treatment, the trial results should be fully and publicly disclosed."
Original Article from The New England Journal of Medicine — Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19
Joseph RossMore evidence that hydroxychloroquine does not improve clinical outcomes of patients hospitalized with #COVID19. Will FDA withdraw the EUA? Will hospitals take HCQ out of their treatment protocols? If not, why not?