Julien Potet
Neglected Tropical Disease advisor tweeting about #NTDs, #snakebite, #mAbs, #Ebola, #malaria, #VaccinesWork, #MSF & of course #COVID19
Last synced from Twitter 20m ago
Tocilizumab for treating COVID-19: a systemic review and meta-analysis of retrospective studies
European Journal of Clinical Pharmacology 4h 1 tweets
COVID-19 has become a global epidemic, and effective therapies have not been discovered up to now. We conducted this study to explore the effectiveness and safety of tocilizumab recently used for treating COVID-19. A comprehensive search was...
Effect of Tocilizumab on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia
Jamanetwork.com 22h 4 tweets
This randomized clinical trial evaluates the effect of early tocilizumab administration vs standard therapy in preventing clinical worsening in patients hospitalized with COVID-19.
Inhaled antibody drug for COVID-19 clears coronavirus in animals
FierceBiotech 10h 1 tweets
An inhaled neutralizing antibody cleared the novel coronavirus from infected hamsters at a far lower dose compared with other experimental monoclonal antibodies. The drug is now being developed by Aridis Pharmaceuticals and could offer a...
Julien Potet While is pushing its high-dose IV anti-SARS2 mAb cocktail (8g !!), researchers are developing inhaled low-dose anti-SARS2 mAbs (2mg-6mg !!). Potentially much cheaper and more user-friendly! 10h
CLINICAL COURSE AND OUTCOME OF COVID-19 ACUTE RESPIRATORY DISTRESS SYNDROME: DATA FROM A NATIONAL REPOSITORY
medRxiv 24h 2 tweets
Background: Mortality attributable to coronavirus disease-19 (COVID-19) 2 infection occurs mainly through the development of viral pneumonia-induced acute respiratory distress syndrome (ARDS). Research Question: The objective of the study is to...
Review of safety and minimum pricing of nitazoxanide for potential treatment of COVID-19 - PubMed
PubMed 25h 1 tweets
Nitazoxanide demonstrates a good safety profile at approved doses. However, further evidence is required regarding hepatorenal and cardiovascular effects, as well as teratogenicity. We estimate that it would be possible to manufacture nitazoxanide...
Just - Evotec Biologics receives grant to enable an antibody product for the prevention of COVID-19 - Evotec
Evotec.com 3d 1 tweets
Development and pre-clinical characterization of two therapeutic equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19
bioRxiv 35h 1 tweets
In the current global emergency due to SARS-CoV-2 outbreak, passive immunotherapy emerges as a promising treatment for COVID-19. Among animal-derived products, equine formulations are still the cornerstone therapy for treating envenomations due to...
Julien Potet Pre-print: in Costa Rica shares the full recipe for their therapeutic equine antiserum for #SARSCoV2. No patent, no trade secret. Other manufacturers can now produce similar products if they wish. This is open science in practice ! 35h
Compassionate Use of Remdesivir for Patients with Severe Covid-19 | NEJM
New England Journal of Medicine 194d 31 tweets
Original Article from The New England Journal of Medicine — Compassionate Use of Remdesivir for Patients with Severe Covid-19
Dutch woman dies after catching Covid-19 twice
CNN 8d 10 tweets
An elderly Dutch woman has become the first known person to die from catching Covid-19 twice, according to experts, raising serious questions about how long immunity and antibodies can last.
The effect of influenza vaccination on trained immunity: impact on COVID-19
medRxiv 5d 2 tweets
Every year, influenza causes 290.000 to 650.000 deaths worldwide and vaccination is encouraged to prevent infection in high-risk individuals. Interestingly, cross-protective effects of vaccination against heterologous infections have been reported,...
NIH begins large clinical trial to test immune modulators for treatment of COVID-19
National Institutes of Health (NIH) 5d 3 tweets
The trial expects to enroll approximately 2,100 hospitalized adults with moderate to severe COVID-19 at medical facilities in the United States and Latin America.
Remdesivir and interferon fall flat in WHO’s megastudy of COVID-19 treatments
Science | AAAS 5d 16 tweets
Solidarity fails to find mortality benefits in four treatments—but the global trial itself wins praise
Chris Christie says he was in ICU for 7 days battling Covid-19, urges Americans to wear masks
NBC News 6d 16 tweets
"As a former public official, I believe we have not treated Americans as adults, who understand truth, sacrifice and responsibility," Christie said in a statement.
Subscribe to read | Financial Times
Ft.com 6d 15 tweets
News, analysis and comment from the Financial Times, the worldʼs leading global business publication
Severe COVID-19 patients display a back boost of seasonal coronavirus-specific antibodies
medRxiv 9d 6 tweets
Severe acquired respiratory syndrome coronavirus-2 (SARS-CoV-2) is the cause of coronavirus disease (COVID-19). In severe COVID-19 cases, higher antibody titers against seasonal coronaviruses have been observed than in mild cases. To investigate...
Julien Potet Two preprints: Seemingly discordant results on the role played by previous infections with seasonal coronavirus in #COVID_19. Seem beneficial in some cases & detrimental in others. 🤔#ADE? 6d
Less severe course of COVID-19 is associated with elevated levels of antibodies against seasonal human coronaviruses OC43 and HKU1 (HCoV OC43, HCoV HKU1)
medRxiv 7d 3 tweets
The clinical course of COVID-19 is very heterogeneous: Most infected individuals can be managed in an outpatient setting, but a substantial proportion of patients requires intensive care, resulting in a high rate of fatalities. Recently, an...
Julien Potet Two preprints: Seemingly discordant results on the role played by previous infections with seasonal coronavirus in #COVID_19. Seem beneficial in some cases & detrimental in others. 🤔#ADE? 6d
How do we tackle the skin NTDs to reach the 2030 NTD road map targets?
World Health Organization 7d 2 tweets
How do we tackle the skin NTDs to reach the 2030 NTD road map targets?
Covid-19 dans les Suds - Société Francophone de Médecine Tropicale et Santé Internationale
Société Francophone de Médecine Tropicale et Santé Internationale 7d 2 tweets
Site de la société Francophone de Médecine Tropicale et Santé Internationale, anciennement appelée Société de Pathologie Exotique
Julien Potet Save The Date: 20 novembre 2020 Webinaire "#Covid_19 dans les Suds" organisé par la Société Francophone de Médecine Tropicale et Santé Internationale Programme et pré-inscription ici 6d
FDA Approves First Treatment for Ebola Virus
U.S. Food and Drug Administration 7d 4 tweets
Today, the FDA approved Inmazeb as the first FDA-approved treatment for Ebola virus infection in adult and pediatric patients.
Exclusive: FDA faults quality control at Lilly plant making Trump-touted COVID drug
U.S. 8d 9 tweets
U.S. drug inspectors uncovered serious quality control problems at an Eli Lilly and Co pharmaceutical plant that is ramping up to manufacture one of two promising COVID-19 drugs touted by President Trump as "a cure" for the disease, according to...