Lucre Snooker
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Efficacy of Convalescent Plasma Therapy compared to Fresh Frozen Plasma in Severely ill COVID-19 Patients: A Pilot Randomized Controlled Trial
medRxiv 87d 2 tweets
Background: The role of convalescent plasma (COPLA) for the treatment of severely ill Corona Virus Disease-2019 is under investigation. We compared the efficacy and safety of convalescent plasma with fresh frozen plasma (FFP) in severe COVID-19...
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Lucre Snooker i'm not saying conv plasma really kills people but when it's associated with 3x higher mortality in a randomized trial i feel like that should be mentioned in the abstract rather than just saying "no significant reduction in mortality was observed" 88d
Influenza in Sweden – 2019-2020 Season — Folkhälsomyndigheten
Folkhalsomyndigheten.se 89d 1 tweets
This report describes the monitoring systems for influenza in use during the winter season of 2019–2020 and the results of both epidemiological and virological surveillance. Data are also compared to previous influenza seasons. The report has been...
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Lucre Snooker another sign that what sweden did was cut social contact (w/o many top-down mandates) as opposed to just continue on with normal life and "allow" many to get infected: the flu season was crushed there too 89d
Mortality among Adults Ages 25-44 in the United States During the COVID-19 Pandemic.
medRxiv 90d 8 tweets
Abstract: Introduction: Coronavirus disease-19 (COVID-19) has caused a marked increase in all-cause deaths in the United States, mostly among adults aged 65 and older. Because younger adults have far lower infection fatality rates, less attention...
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Lucre Snooker in some areas, at least, COVID deaths among younger people (25-44) are comparable to opioid deaths 90d
CLINICAL COURSE AND OUTCOME OF COVID-19 ACUTE RESPIRATORY DISTRESS SYNDROME: DATA FROM A NATIONAL REPOSITORY
medRxiv 94d 2 tweets
Background: Mortality attributable to coronavirus disease-19 (COVID-19) 2 infection occurs mainly through the development of viral pneumonia-induced acute respiratory distress syndrome (ARDS). Research Question: The objective of the study is to...
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Lucre Snooker this data from the VA on 30-day mortality from ARDS (h/t ) is retrospective but yeesh, that's a big effect for "anticoagulant" 94d
Use of convalescent serum reduces severity of COVID-19 in nonhuman primates
bioRxiv 100d 3 tweets
Passive transfer of convalescent plasma or serum is a time-honored strategy for treating infectious diseases. Human convalescent plasma containing antibodies against SARS-CoV-2 is currently being used to treat COVID-19 patients. However, most...
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Lucre Snooker convalescent plasma in monkeys: they say it "reduces severity" but it's not particularly convincing. even administered just 10 hrs after viral challenge it barely alters viral load (blue is low-titer, green high, white control) 100d
Americans are divided over the type of instruction K-12 schools should provide in the fall
Pew Research Center 101d 1 tweets
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Lucre Snooker according to this Pew poll from august, "lower income" people were MORE likely to support online-only school and less likely to support in-person school 101d
Clinical, laboratory, and temporal predictors of neutralizing antibodies to SARS-CoV-2 after COVID-19
medRxiv 107d 3 tweets
Background: SARS-CoV-2-specific antibodies may protect from reinfection and disease, providing the rationale for administration of plasma containing SARS-CoV-2 neutralizing antibodies (nAb) as a treatment for COVID-19. The clinical factors and...
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Lucre Snooker this graph is telling you that infected people who are seronegative (not common) also don't have high levels of detectable t cells. and pre-pandemic blood samples don't either. oh well 107d
Obesity and Mortality Among Patients Diagnosed With COVID-19: Results From an Integrated Health Care Organization | Annals of Internal Medicine
Acpjournals.org 163d 9 tweets
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Lucre Snooker study using Kaiser data from southern CA seems to say that mortality improved a lot over time, even adjusted for BMI/age/sex/race/comorbidities 162d
Coronavirus Vaccine Update, June 29
In the Pipeline 207d 7 tweets
More vaccine news to catch up on - previous updates and specific topic posts on this subject were on June 15, on June 11, on May 26, on May 18 (with two other posts), on May 14, on May 1, on April 23, and on April 15 (author's note: yikes). Keep in...
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Lucre Snooker this is also what says it is ("the Russian GRI vaccine is a mixture of Ad5 and Ad26 vectors") 165d
Safety and immunogenicity of GamEvac-Combi, a heterologous VSV- and Ad5-vectored Ebola vaccine: An open phase I/II trial in healthy adults in Russia
PubMed Central (PMC) 165d 1 tweets
Ebola hemorrhagic fever, also known as Ebola virus disease or EVD, is one of the most dangerous viral diseases in humans and animals. In this open-label, dose-escalation clinical trial, we assessed the safety, side effects, and immunogenicity of a...
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Lucre Snooker anyone have any details about the Russian vaccine? i've pieced together from a few articles that it's probably the same setup as the gamaleya ebola vaccine, which was a live attenuated VSV vector as prime and a replication-defective Ad5 as boost 165d
On the molecular mechanism of SARS-CoV-2 retention in the upper respiratory tract
bioRxiv 177d 1 tweets
Cell surface receptor engagement is a critical aspect of viral infection. At low pH, binding of SARS-CoV and its ACE2 receptor has a tight interaction that catalyzes the fusion of the spike and endosomal membranes followed by genome release. Largely...
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Lucre Snooker posting more intranasal propaganda just to feel something 177d
Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates
Nature 185d 15 tweets
Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates
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Lucre Snooker also doesn’t work in monkeys 181d
Comparing influenza vaccine efficacy against mismatched and matched strains: a systematic review and meta-analysis
BMC Medicine 242d 1 tweets
Influenza vaccines are most effective when the antigens in the vaccine match those of circulating strains. However, antigens contained in the vaccines do not always match circulating strains. In the present work we aimed to examine the vaccine...
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Lucre Snooker there's probably a newer study but a 2013 meta-analysis of RCTs () says that, for the inactivated-virus vaccine, effectiveness was 52% against "mismatched" strains but still only 65% against *matched* strains 242d
Mumbai: Impact of HCQ on cops not monitored, some say it gives psychological boost
The Indian Express 247d 1 tweets
The drug, which has been pushed by US President Donald Trump as a “game changer” in the fight against Covid-19, is in demand in many parts of the world. But its efficacy is still being clinically tested.
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Lucre Snooker meanwhile a different Indian newspaper says "impact of HCQ on cops not monitored...the city police does not have a system in place yet to monitor the medicine’s effects on its personnel" 247d
Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 - implications for microvascular inflammation and hypercoagulopathy in COVID-19 patients
bioRxiv 255d 1 tweets
Accumulating clinical observations suggest pathogenesis beyond viral pneumonia and its secondary consequences in COVID-19 patients. In particular, many patients develop profound hyperinflammation and hypercoagulopathy with disseminated...
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Lucre Snooker this seems important in making sense of the weird coagulation stuff — pericytes (cells that wrap around endothelial cells) express a lot of ACE2 but can only be reached by the virus if your endothelium is already leaky? 255d
SARS-CoV-2 ORF3b is a potent interferon antagonist whose activity is further increased by a naturally occurring elongation variant
bioRxiv 256d 4 tweets
One of the features distinguishing SARS-CoV-2 from its more pathogenic counterpart SARS-CoV is the presence of premature stop codons in its ORF3b gene. Here, we show that SARS-CoV-2 ORF3b is a potent interferon antagonist, suppressing the induction...
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Lucre Snooker quasispecies, eh? 😬 256d
The diagnosis and classification of Henoch–Schönlein purpura: An updated review
Sciencedirect.com 257d 1 tweets
Henoch–Schönlein purpura (HSP) is a common childhood systemic vasculitis with clinical characteristics of cutaneous palpable purpura, arthralgia/arthr…
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Lucre Snooker there's a condition called "Henoch–Schönlein purpura, a systemic small vessel vasculitis that occurs commonly in children" and may be a side effect of immune responses to upper-respiratory-tract infection... 257d
Anti-endothelial cell antibodies from patients with thrombotic thrombocytopenic purpura specifically activate small vessel endothelial cells
OUP Academic 258d 1 tweets
Abstract. Thrombotic thrombocytopenic purpura (TTP) is an uncommon disease of an unknown etiology, characterized by consumptive thrombocytopenia, microangiopat
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Lucre Snooker anti-endothelial-cell antibodies are associated with thrombotic thrombocytopenic purpura, and these antibodies cause endothelial cells to secrete IL-6 and von Willebrand factor (associated with clotting) 😨 258d
Autoimmune Aspects of Kawasaki Disease - PubMed
PubMed 258d 1 tweets
Kawasaki disease (KD) is a vasculitis that is part of systemic vasculitis syndrome. It affects medium-sized vessels and is characterized by hypercytokinemia. Although the etiology of KD remains unidentified, epidemiological features point to the...
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Lucre Snooker one theory is that Kawasaki is caused by antibodies against endothelial cells, “accidentally” produced in response to an infection () 258d
Identification of IgG antibody response to SARS-CoV-2 spike protein and its receptor binding domain does not predict rapid recovery from COVID-19
medRxiv 262d 1 tweets
Diagnostic testing and evaluation of patient immunity against the novel severe acute respiratory syndrome (SARS) corona virus that emerged last year (SARS-CoV-2) are essential for health and economic crisis recovery of the world. It is suggested...
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Lucre Snooker antibodies not obviously correlated with good outcomes 262d