In a small study in San Francisco, Abbott’s BinaxNOW identified infectious people nearly as accurately as a P.C.R. test.
Michael Lin, PhD-MDVery interesting study in several ways. 16 high-titer positives by PCR out of 878 BART riders, 10 low-titer. With high-titer period of ~1 week per infection, this suggests 16/878 = 1.8% of the sample population is getting COVID19 each week. That's high...
Harvey Alter of the NIH, Michael Houghton of the University of Alberta, and Charles Rice of the Rockefeller University share the prize.
Michael Lin, PhD-MDCongrats to Alter, Houghton, and Rice! Incidentally, this announcement is relevant for COVID-19 too. Our own research finds that an anti-HCV drug serves as a good template for new COVID-19 drugs. See #ML1000
(Both HCV and SARSCoV2 are RNA viruses)
TARRYTOWN, N.Y. , Sept. 29, 2020 /PRNewswire/ -- Greatest improvements in patients who had not mounted their own effective immune response prior to treatment Plan rapidly to discuss results with regulatory authorities Regeneron to host investor...
Michael Lin, PhD-MDI've been meaning to cover the promising results from Regeneron on their monoclonal antibody REGN-CoV2 for early-stage COVID-19, but wanted to finish a paper and grant application first. Given today's events, we'll do the REGN-CoV2 discussion first.
The main protease, Mpro, of SARSCoV2 is a key protein in the coronavirus life cycle and a major drug target. Based on crystal structures of SARSCoV2 Mpro complexed with peptidomimetic inhibitors, we recognized a structural motif shared with approved...
Michael Lin, PhD-MDTHREAD Today we reveal a new drug candidate for COVID19 from my lab at Stanford. Our drug potently inhibits the SARSCoV2 protease, and is the result of intense work we began the week shutdown began in March. The results so far are good. Quite good. (1/n)
COVID-19 Clinical Research Trial Listings on CenterWatch
Michael Lin, PhD-MDIf you just got COVID19, have a family member with it, or work/live in a nursing home, you might want to enroll in a trial of monoclonal antibodies to treat/prevent disease.
You can click below, enter your location, and look for REGN-CoV2 or LY-CoV555
Genetically encoded voltage indicators (GEVIs) could potentially be used for mapping neural circuits at the plane of synaptic potentials and plateau potentials – two blind spots of GCaMP-based imaging. In the last year alone, several laboratories...
One of the country's most prominent Black Republicans, Herman Cain was a candidate in the 2012 GOP presidential primary.
Michael Lin, PhD-MDWhy is this not today's top headline? Former POTUS candidate Herman Cain has died from coronavirus. Attended the Tulsa rally, didn't wear a mask, diagnosed 2 weeks later.
Evidence the reelection campaign is spreading death and disease to its supporters.
Of 1,400 Israelis diagnosed with COVID-19 last month, 657 (47 percent) were infected in schools. Now 2,026 students, teachers, and staff have it, and 28,147 are quarantined.
Michael Lin, PhD-MDIn Israel, opening all schools to all grades is driving record levels of infections there. Half of cases are contracted at school. Middle-schoolers are the most likely to spread virus. An earlier test of grades 1-3 in small groups seemed okay.
The W.H.O. has resisted mounting evidence that viral particles floating indoors are infectious, some scientists say. The agency maintains the research is still inconclusive.
Michael Lin, PhD-MDEven WHO consultants have had enough of WHO's refusal to recognize possible transmission mechanisms. A public health agency should be suggesting easy measures if they are likely to help, not waiting for incontrovertible proof in this particular pandemic.
California, the most populous US state and the first to implement a statewide lockdown to combat the coronavirus outbreak, is setting daily records this week for new cases as officials urge caution and dangle enforcement threats to try to curb the...
Michael Lin, PhD-MDMeanwhile WHO states:
• If you are healthy, you only need to wear a mask if you are taking care of a person with COVID-19.
• Masks are effective only when used in combination with frequent hand-cleaning
Both statements are contradicted by evidence (4/4)
The findings of this systematic review and meta-analysis support physical distancing
of 1 m or more and provide quantitative estimates for models and contact tracing to
inform policy. Optimum use of face masks, respirators, and eye protection in...
Michael Lin, PhD-MDThe benefit of face masks for protecting wearers from COVID-19 may be bigger than anyone expected: 85-95%. This is based on two meta-analyses. The first below estimated 85% benefit (1/4)
After initial setbacks, the country's recent antibody screen estimates that 5 percent of the population has been exposed to SARS-CoV-2.
Michael Lin, PhD-MDSo yes COVID-19 is > 10x more lethal than flu. Yes shutdowns have worked to limit spread. Yes continued distancing and face masks are required. Yes 20x more people can still die. Here's a good article with further links if you are interested (6/n)
The global COVID-19 pandemic caused by the SARS-CoV-2 virus has made the development of a vaccine a top biomedical priority. In this study, we developed a series of DNA vaccine candidates expressing different forms of the SARS-CoV-2 Spike (S)...
Michael Lin, PhD-MDA very exciting study has been published showing a DNA vaccine protects monkeys against COVID19. As far as I can tell, this is a gift box with lots of good news which I will go through below (1/n)
Despite indifferent lockdowns and poor testing, Japan seems to be skipping the worst of the pandemic.
Michael Lin, PhD-MDIt's clear why the virus is dying out in Japan even as most businesses stay open: widespread mask use (similar to Korea). Yet many of our press and politicians refuse to believe it. We would rather lose lives and jobs than wear masks. It's insane.