COVID-19 poses the greatest threat to older people, but vaccines often don’t work well in this group. Scientists hope drugs that rejuvenate the immune system will help.
Matt KaeberleinThrilled @nature is paying attention. We must address aging as the greatest risk factor for disease (including COVID) if we ever hope get more than incremental successes in biomedicine.
How anti-ageing drugs could boost COVID vaccines in older people
Rapalogs, inhibitors of mTORC1 (mammalian target of rapamycin complex 1), increase lifespan and delay age-related phenotypes in many species. However the molecular mechanisms have not been fully elucidated. We determined gene expression changes...
Matt KaeberleinImportant paper from @davidjglassMD showing 6 weeks treatment with a rapamycin-derivative rejuvenates aged kidney. Heart, brain, intestine, immune, kidney... Anyone still believe that rapamycin *only* prevents cancer with "limited effects on aging"?