Our results suggest that ERBB2 plays a previously unrecognized role in EGFR L861Q-driven tumorigenesis, and pan-ERBB inhibitors are likely to be more effective than selective EGFR tyrosine kinase inhibitors in this setting.
Marc LadanyiAllele-specific role of ERBB2 in the oncogenic function of EGFR L861Q in EGFR-mutant lung cancers 👉 key message: afatinib may be better than osi in this molecular subset #LCSM
Environmental exposures shape patterns of selection for mutations in clonal hematopoiesis. Cancer therapies promote the growth of clones with mutations that are strongly enriched in treatment-related myeloid neoplasms.
Purpose: Patients with alveolar soft part sarcoma (ASPS) are rare and have few treatment options. We assessed the activity of geptanolimab (GB226), a fully humanized PD-1 antibody, for patients with unresectable, recurrent or metastatic ASPS....
How the world’s greatest public health organization was brought to its knees by a virus, the president and the capitulation of its own leaders, causing damage that could last much longer than the coronavirus.
Even for a conservative religious community, the People of Praise is notable in how deeply embedded members are in one another’s lives.
Marc Ladanyi"Until recently, the group used the term “handmaids” to refer to female leaders" 👉This is NOT mainstream catholicism, it is a cult. Like any fundamentalist cult, it's anti-rational & totalitarian. Questioning this is NOT "anti-catholic". #HandmaidAmy #ACB
President Trump is back on the campaign trail and he’s having more fun than ever! Trump held a massive rally in Sanford, Florida Monday evening. The President recovered from Covid-19 and he’s full of energy. Trump had fun dancing to the Village...
ew fusion genes by RNA-sequencing, thus expanding the molecular spectrum of this entity. All patients except 1 were children and infants. The tumors, frequently located in the head (n=8), had a mean size of 38 mm (range 10 to 150 mm) and were mostly...
Unlike common EGFR mutations, many less common EGFR mutations remain poorly characterized
in terms of oncogenic function and drug sensitivity. Herein, we characterize the subset
of lung adenocarcinoma harboring EGFR L861Q through both preclinical...