McHeyzer-Williams
#Immunology | #SingleCell #Immunity | #ImmuneMemory | YouTube | Latest,
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T cell regeneration after immunological injury
Nature Reviews Immunology 91d 4 tweets
Reconstitution of the immune system after depletion by chemotherapy, radiotherapy, infection or transplantation is crucial to maintain protection from infection and to respond to immune-based therapy. Here the authors describe the ways in which a...
McHeyzer-Williams #T_cell_Regeneration | after immunological injury | Overview of the dynamics after HSC transplant | Marcel van den Brink 87d
γδ T cells in tissue physiology and surveillance
Nature Reviews Immunology 101d 3 tweets
This Review focuses on the roles of γδ T cells in tissue homeostasis and immune surveillance. The authors discuss exciting new studies showing how γδ T cells can regulate diverse physiological responses in tissues, ranging from thermogenesis in...
McHeyzer-Williams γδ T cells | tissue physiology and surveillance | homeostasis in tissues | Bruno Silva-Santos 86d
McHeyzer-Williams γδ T cells | tissue physiology and surveillance | Developmental Waves | Bruno Silva-Santos 87d
β-Coronaviruses use lysosomes for egress instead of the biosynthetic secretory pathway
Sciencedirect.com 87d 2 tweets
β-Coronaviruses are a family of positive-strand enveloped RNA viruses that include the severe acute respiratory syndrome-CoV2 (SARS-CoV2). Much is kno…
McHeyzer-Williams β-Coronaviruses use lysosomes for egress instead of the biosynthetic secretory pathway | Nihal Altan-Bonnet 87d
McHeyzer-Williams β-Coronaviruses use lysosomes for egress instead of the biosynthetic secretory pathway | Nihal Altan-Bonnet 87d
CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10
Cell 87d 3 tweets
A multimodal investigation into the tumor microenvironment of brain metastases in mouse models demonstrates the central role of CNS-resident myeloid populations in creating an immunosuppressive pro-metastatic microenvironment.
McHeyzer-Williams #Myeloid_Cells in #Brain_Metastases | CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10 | Siyuan Zhang 87d
McHeyzer-Williams #Myeloid_Cells in #Brain_Metastases | CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10 | Siyuan Zhang 87d
A distinct GM-CSF+ T helper cell subset requires T-bet to adopt a TH1 phenotype and promote neuroinflammation
Science Immunology 91d 4 tweets
Production of GM-CSF by T helper cells not only guides adaptive immune responses but also can contribute to the pathogenesis of autoimmune disease. Rasouli et al. used single-cell RNA sequencing, mass cytometry, and GM-CSF fate mapper mice to...
McHeyzer-Williams #TH1_Phenotype and #nNeuroInflammation | A distinct GM-CSF+ T helper cell subset that requires T-bet | Abdolmohamad Rostami 87d
McHeyzer-Williams #TH1_Phenotype and #nNeuroInflammation | A distinct GM-CSF+ T helper cell subset that requires T-bet | Abdolmohamad Rostami 87d
McHeyzer-Williams #TH1_Phenotype and #nNeuroInflammation | A distinct GM-CSF+ T helper cell subset that requires T-bet | Abdolmohamad Rostami 88d
A new neutrophil subset promotes CNS neuron survival and axon regeneration
Nature Immunology 88d 4 tweets
Segal and colleagues identify a neuroprotective immature-like neutrophil subset that participates in dectin-1-dependent axon repair and regeneration in the central nervous system.
McHeyzer-Williams A new #Neutrophil_Subset | promotes CNS neuron survival and axon regeneration | Benjamin Segal 87d
McHeyzer-Williams A new #Neutrophil_Subset | promotes CNS neuron survival and axon regeneration | Benjamin Segal 87d
McHeyzer-Williams A new #Neutrophil_Subset | promotes CNS neuron survival and axon regeneration | Benjamin Segal 88d
Early emergence of T central memory precursors programs clonal dominance during chronic viral infection
Nature Immunology 88d 3 tweets
T cell memory formation is often described as occurring during the chronic phases of infection. Buchholz and colleagues use the phenomenon of ‘memory inflation’ following cytomegalovirus infection to show that a tiny subset of self-renewing T cells...
McHeyzer-Williams #CD8_T_CentralMemory precursors | Early emergence programs clonal dominance during #ChronicViral_Infection | Veit Buchholz 87d
McHeyzer-Williams #CD8_T_CentralMemory precursors | Early emergence programs clonal dominance during #ChronicViral_Infection | Veit Buchholz 88d
McHeyzer-Williams #CD8_T_CentralMemory precursors | Early emergence programs clonal dominance during #ChronicViral_Infection | Veit Buchholz 88d
A new lymphoid-primed progenitor marked by Dach1 downregulation identified with single cell multi-omics
Nature Immunology 95d 6 tweets
Exploring transcriptional heterogeneity of cKit+Sca1+ HSPCs using single cell RNA-sequencing, Naik and colleagues identify a population termed ‘lymphoid primed progenitors’ as the earliest stage of lymphoid lineage commitment, marked by...
McHeyzer-Williams A new #Lymphoid_Primed #Progenitor marked by Dach1 downregulation | Shalin Naik 87d
McHeyzer-Williams A new #Lymphoid_Primed #Progenitor marked by Dach1 downregulation | Shalin Naik 88d
McHeyzer-Williams A new #Lymphoid_Primed #Progenitor marked by Dach1 downregulation | Shalin Naik 88d
Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens
Immunity 91d 4 tweets
Dendritic cells are required for the initiation of the allergic immune response, but it is unclear how they sense allergens. Perner et al. reveal that allergen-induced Substance P release by TRPV1+ sensory neurons triggers MRGPRA1-dependent...
McHeyzer-Williams Substance P Release by #SensoryNeurons Triggers #DendriticCell_Migration and Initiates the #Type2_ImmuneResponse to #Allergens | Caroline Sokol 88d
McHeyzer-Williams Substance P Release by #SensoryNeurons Triggers #DendriticCell_Migration and Initiates the #Type2_ImmuneResponse to #Allergens | Caroline Sokol 88d
McHeyzer-Williams Substance P Release by #SensoryNeurons Triggers #DendriticCell_Migration and Initiates the #Type2_ImmuneResponse to #Allergens | Caroline Sokol 89d
Neuroinflammation after surgery: from mechanisms to therapeutic targets
Nature Immunology 89d 2 tweets
Terrando and colleagues review key mechanisms related to postoperative inflammation and the implications for developing perioperative neurocognitive disorders, with a focus on neuroinflammation and key cellular targets affected by surgical trauma.
McHeyzer-Williams #NeuroInflammation after surgery | from mechanisms to therapeutic targets | Neuro–immune interactions in the brain | Niccolò Terrando 88d
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McHeyzer-Williams #NeuroInflammation after surgery | from mechanisms to therapeutic targets | Innate immune response | Niccolò Terrando 89d
Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses
Immunity 89d 3 tweets
Polyreactivity is a common feature of antibodies, but little is known about the selection, function, and role of polyreactive B cells against pathogens. Guthmiller et al. demonstrate polyreactive B cells are selected against broadly neutralizing...
McHeyzer-Williams #PandemicThreat #Influenza_Viruses | Polyreactive Broadly Neutralizing B cells are selected to Provide Defense | Patrick Wilson 88d
McHeyzer-Williams #PandemicThreat #Influenza_Viruses | Polyreactive Broadly Neutralizing B cells are selected to Provide Defense | Patrick Wilson 88d
McHeyzer-Williams #PandemicThreat #Influenza_Viruses | Polyreactive Broadly Neutralizing B cells are selected to Provide Defense | Patrick Wilson 89d
A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization
Immunity 89d 3 tweets
Yewdell et al. examine the contribution of G-quadruplex (G4) nucleic acid structures to AID targeting in vivo using mice bearing a mutation in Aicda found in hyper-IgM syndrome patients. Their findings reveal a crucial role for G4 binding in AID...
McHeyzer-Williams #HyperIgM_Syndrome | A Mutation in AICDA Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization | Jay Chaudhuri 88d
McHeyzer-Williams #HyperIgM_Syndrome | A Mutation in AICDA Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization | Jay Chaudhuri 89d
McHeyzer-Williams #HyperIgM_Syndrome | A Mutation in AICDA Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization | Jay Chaudhuri 89d
Proximal colon–derived O-glycosylated mucus encapsulates and modulates the microbiota
Science 90d 3 tweets
Mammals accommodate a dense community of metabolically active microorganisms in their gut. This is not a passive relationship, and host and microbe have antagonistic as well as mutualistic responses to each other. Using a whole-colon imaging method...
McHeyzer-Williams Proximal colon–derived O-glycosylated mucus encapsulates and modulates #Microbiota | Lijun Xia 89d
McHeyzer-Williams Proximal colon–derived O-glycosylated mucus encapsulates and modulates #Microbiota | Lijun Xia 89d
McHeyzer-Williams Proximal colon–derived O-glycosylated mucus encapsulates and modulates #Microbiota | Lijun Xia 90d
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors
Science 90d 4 tweets
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is decorated with spikes, and viral entry into cells is initiated when these spikes bind to the host angiotensin-converting enzyme 2 (ACE2) receptor. Many monoclonal antibody therapies in...
McHeyzer-Williams #SARSCoV2 | De novo design of picomolar #Miniprotein_Inhibitors | David Baker 89d
McHeyzer-Williams #SARSCoV2 | De novo design of picomolar #Miniprotein_Inhibitors | David Baker 89d
McHeyzer-Williams #SARSCoV2 | De novo design of picomolar #Miniprotein_Inhibitors | David Baker 90d
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
Science 90d 3 tweets
The immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals that lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody system dampens...
McHeyzer-Williams Life-threatening #COVID19 | Autoantibodies against type I IFNs in patients | Jean-Laurent Casanova 89d
McHeyzer-Williams Life-threatening #COVID19 | Autoantibodies against type I IFNs in patients | Jean-Laurent Casanova 90d
McHeyzer-Williams Life-threatening #COVID19 | Autoantibodies against type I IFNs in patients | Jean-Laurent Casanova 90d
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Science 91d 3 tweets
The immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals that lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody system dampens...
McHeyzer-Williams #Life_Threatening #COVID19 | Inborn errors of type I IFN immunity | Jean-Laurent Casanova 90d
McHeyzer-Williams #Life_Threatening #COVID19 | Inborn errors of type I IFN immunity | Jean-Laurent Casanova 90d
McHeyzer-Williams #Life_Threatening #COVID19 | Inborn errors of type I IFN immunity | Jean-Laurent Casanova 91d
Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin
Cell 92d 7 tweets
SHARE-seq, a highly scalable approach to measure chromatin accessibility and gene expression in the same single cell, links distal regulatory elements to key lineage-specifying genes and finds that chromatin accessibility foreshadows gene expression.
McHeyzer-Williams #Chromatin_Potential by #SHARE_Seq | Chromatin accessibility lineage-priming predicts #CellFate_Decisions | Jason Buenrostro 90d
McHeyzer-Williams #Chromatin_Potential by #SHARE_Seq | Chromatin accessibility lineage-priming predicts #CellFate_Decisions | Jason Buenrostro 90d
McHeyzer-Williams #Chromatin_Potential | Chromatin accessibility lineage-priming predicts #CellFate_Decisions | Jason Buenrostro 91d
Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation
Cell 91d 4 tweets
FucoID enables identification of endogenous tumor antigen-specific T cells based on an interaction-dependent fucosyl-biotinylation.
McHeyzer-Williams #Tumor #AntigenSpecific_T_Cells | Detecting via Interaction-Dependent Fucosyl-Biotinylation | Peng Wu 90d
McHeyzer-Williams #Tumor #AntigenSpecific_T_Cells | Detecting via Interaction-Dependent Fucosyl-Biotinylation | Peng Wu 91d
McHeyzer-Williams #Tumor #AntigenSpecific_T_Cells | Detecting via Interaction-Dependent Fucosyl-Biotinylation | Peng Wu 91d
Co-option of Neutrophil Fates by Tissue Environments
Cell 92d 4 tweets
Neutrophils demonstrate plasticity in form and function depending upon the tissue types.
McHeyzer-Williams #Neutrophil_Fates | acquire distinct phenotypic and functional properties in tissues | Andrés Hidalgo 90d
McHeyzer-Williams #Neutrophil_Fates | acquire distinct phenotypic and functional properties in tissues | Andrés Hidalgo 91d
McHeyzer-Williams #Neutrophil_Fates | acquire distinct phenotypic and functional properties in tissues | Andrés Hidalgo 91d
Plasma Proteomics Identify Biomarkers and Pathogenesis of COVID-19
Immunity 93d 3 tweets
The COVID-19 pandemic is a global public health crisis. However, little is known about the pathogenesis and biomarkers of COVID-19. Herein, we profiled host responses to COVID-19 by performing plasma proteomics of a cohort of COVID-19 patients...
McHeyzer-Williams #Pathogenesis of #COVID19 | Plasma Proteomics Identify Biomarkers | Xi Zhou #CAS_Wuhan 92d
McHeyzer-Williams #Pathogenesis of #COVID19 | Plasma Proteomics Identify Biomarkers | Xi Zhou #CAS_Wuhan 92d
McHeyzer-Williams #Pathogenesis of #COVID19 | Plasma Proteomics Identify Biomarkers | Xi Zhou #CAS_Wuhan 93d