A popular artificial-intelligence method provides a powerful tool for surveying and classifying biological data. But for the uninitiated, the technology poses significant difficulties.
Robert PlengeWhat is AI's "sweet spot" for drug discovery?
If 15,000 is apx. number of true events needed to train AI algorithms, then only some applications relevant:
Good = imaging, small molecule binders
Bad = novel drug targets from genomic data
Flatiron’s key insight was that, in cancer, half or more of the most important data in health records isn’t in structured data fields, but rather in unstructured data, the free text fields of pathology reports and clinical notes, and extracting this...
Robert PlengeExcellent perspective by @DShaywitz on health tech companies delivering value to front-end (eg, oncologists) and back-end (eg, pharma) stakeholders.
Also shout out to the Mechanical Turk.
The flow of capital into global biotech startups is turning from a flood into a tsunami. 2018 has already seen more $50 million+ Series A rounds than the whole of 2008, writes David J. Grainger. By January 4, China’s DTRM Biopharma and CMAB raised...
Robert Plenge“As the public loses patience with rising drug costs, the focus must fall ever more sharply on the efficiency of the R & D process itself.”
Robert Plenge“Too much capital is more destructive to productivity..than too little. Most obviously, plentiful capital chasing a fixed number of assets drives up prices, until at some point (a point we may already have passed) they exceed risk-adjusted value.”
Robert Plenge“But the silent casualty, capital productivity, will eventually turn round and bite us all.”
Background: Type 1 diabetes (T1D) results from loss of immune regulation leading to the development of autoimmunity to pancreatic beta-cells, involving autoreactive T effector cells (Teffs). Regulatory T cells (Tregs), that prevent autoimmunity,...
<p>Psoriasis is a chronic, immune-mediated disease that can severely affect patient
quality of life. Various kinds of skin manifestations are possible; psoriatic
arthritis is a common but underdiagnosed...
Long ago, in and around Harvard Square, these visionaries saw the potential of biotech and software — and then made it reality.
Robert PlengeEarly origins of the Boston-Cambridge biotech revolution: Cambridge studied the risks and potential benefits of recombinant DNA; in 1977 it became the first city in the world to set regulations for working with genetic material.
Neuronal synapse formation and remodeling is essential to central nervous system (CNS) development and is dysfunctional in neurodevelopmental diseases. Innate immune signals regulate tissue remodeling in the periphery, but how this impacts CNS...
Polymorphisms in C1orf106 are associated with increased risk of inflammatory bowel disease (IBD). However, the function of C1orf106 and the consequences of disease-associated polymorphisms are unknown. Here we demonstrate that C1orf106 regulates...
Type 1 diabetes (T1D) is associated with enrichment of autoreactive CD8+ T cells that target destruction of pancreatic islets. Culina et al . studied islet-reactive CD8+ T cells reactive to the zinc transporter 8186–194 (ZnT8186–194) and other islet...
Most neurons that make up the human brain are postmitotic, living and functioning for a very long time without renewal (see the Perspective by Lee). Bae et al. examined the genomes of single neurons from the prenatal developing human brain. Both the...