Sam Modlin
Graduate student - pathogen genomics. Trying to help us understand how molecules give rise to life
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Drivers and sites of diversity in the DNA adenine methylomes of 93 Mycobacterium tuberculosis complex clinical isolates
eLife 127d 1 tweets
Fully assembled DNA methylomes from phylogeographically diverse clinical Mycobacterium tuberculosis complex isolates reveals 'intercellular mosaic methylation' as a source of epigenetic diversity.
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Sam Modlin Our work on DNA methylation in M. tuberculosis is finally out in ! Using sequencing kinetics and long reads, we fully assembled DNA methylomes from 93 phylogeographically diverse clinical Mycobacterium tuberculosis complex isolates. (1/7) 127d
Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections
Nature Medicine 259d 42 tweets
A cohort of asymptomatic patients infected with SARS-CoV-2 had significantly lower levels of virus-specific IgG antibodies compared to a cohort of age- and sex-matched symptomatic infected patients.
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Sam Modlin Could use more patients, but this is stunning: 1. Asymptomatic patients (n=37) shed virus for longer than sympt patients (P=0.028) 2. 21/37 of asymptomatic patients had covid-associated lung abnormalities on their CT-scan 257d