Sean Cavanagh
PhD student at UCL Institute of Neurology. Interested in how the brain makes decisions.
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A circuit mechanism for decision-making biases and NMDA receptor hypofunction
Ketamine, an NMDA receptor antagonist and experimental model for schizophrenia, produces decision-making deficits in monkeys, which are predicted by a lowering of cortical excitation-inhibition balance in a spiking circuit model.
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Sean Cavanagh
Our paper 'A circuit mechanism for decision making biases and NMDA receptor hypofunction’ is out in @eLife !
This is work with Norman Lam (co-lead author), @johndmurray, @LHuntNeuro, and Steve Kennerley [1/15]
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A circuit mechanism for irrationalities in decision-making and NMDA receptor hypofunction: behaviour, computational modelling, and pharmacology
Decision-making biases can be systematic features of normal behaviour, or deficits underlying neuropsychiatric symptoms. We used behavioural psychophysics, spiking-circuit modelling and pharmacological manipulations to explore decision-making biases...
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Sean Cavanagh
Our new paper, (with Norman Lam, @johndmurray, @LHuntNeuro, and Steve Kennerley is on Biorxiv!
490d
Visual fixation patterns during economic choice reflect covert valuation processes that emerge with learning
Where we direct our gaze can have a big impact on what we choose. However, where we choose to gaze during the decision process is not well-characterized, despite the important role it plays. In our study, monkeys performed a simple decision-making...
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Sean Cavanagh
Our paper 'Visual fixation patterns during economic choice reflect covert valuation processes that emerge with learning' is out in @PNASNews!
This is work with Nish Malalasekera (joint first author), Bruno Miranda, @LHuntNeuro
and Steve Kennerley [1/8]
501d
Reconciling persistent and dynamic hypotheses of working memory coding in prefrontal cortex
Working memory (WM) is represented in persistent activity of single neurons as well as a dynamic population code. Here, the authors find that neurons flexibly switch their coding according to current attention while those with stable resting...
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Sean Cavanagh
Our paper 'Reconciling persistent and dynamic hypotheses of working memory coding in prefrontal cortex' is out in @NatureComms!
This is work with John Towers, Joni Wallis, @LHuntNeuro and Steve Kennerley that we first posted on BiorXiv in December. [1/n]
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