Annals.org

Sobieraj DM, Martinez BK, Hernandez AV, et al. Adverse effects of pharmacologic treatments of major depression in older adults. J Am Geriatr Soc. 2019;67:1571-81. 31140587

States regulate health insurance, medical benefits, and the clinicians who provide care, and some states are exploring ways to use that power to fill coverage gaps that remain after passage of the Patient Protection and Affordable Care Act. The...

Background: Both pharmacologic and nonpharmacologic interventions are used to treat neuropsychiatric symptoms in persons with dementia. Purpose: To summarize the comparative efficacy of pharmacologic and nonpharmacologic interventions for...

“Overdose! Out front!” the shelter staff member yelled through the door of our shelter-based clinic.

I have always rejected the idea that people with cancer should be described as “fighters.” Because many of my patients will not survive this disease, I felt that the fighting metaphor set them up for failure. If they died, they had not fought hard...

Background: The potential role of new oral anticoagulants in antiphospholipid antibody syndrome (APS) remains uncertain. Objective: To determine whether rivaroxaban is noninferior to dose-adjusted vitamin K antagonists (VKAs) for thrombotic...

The competition for funds to conduct clinical research is intense, and only a minority of grant proposals receive funding. In particular, funding for patient-oriented research lags behind that allocated for basic science research. Grant writing is a...

Two chemotherapy regimens for treatment of patients with advanced Hodgkin's disease, BCVPP (carmustine, cyclophosphamide, vinblastine, procarbazine, and prednisone) and MOPP (mechlorethamine hydrochloride, vincristine, procarbazine, and prednisone),...

The American College of Cardiology/American Heart Association updated their cholesterol guidelines in November 2013, sparking debate about the role of statins in the primary prevention of cardiovascular disease. In response, this commentary...

Background: Studying dietary patterns may provide insights into the potential effects of red and processed meat on health outcomes. Purpose: To evaluate the effect of dietary patterns, including different amounts of red or processed meat, on...

Many support limiting firearm access for persons whose mental illness would place them or others at heightened risk, but less attention has been paid to progressive cognitive impairment and firearm access. For persons with dementia, discussions...

Antibiotic resistance has been a major concern in the past few decades. Current initiatives to incentivize the development of antibiotics for resistant pathogens have yielded disappointing results because many recently approved antibiotics do not...

Background: Whether health care provider burnout contributes to lower quality of patient care is unclear. Purpose: To estimate the overall relationship between burnout and quality of care and to evaluate whether published studies provide...

Background: Central line–associated bloodstream infection (CLABSI) remains prevalent in hospitals in the United States. Objective: To evaluate the impact of a multimodal intervention in hospitals with elevated rates of health care–associated...

Health care continues to change rapidly, growing increasingly complex with greater acuity of patients, delivery of more care outside of traditional acute care settings, and ongoing challenges related to staffing and personnel turnover. Despite this,...