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Despite initial responsiveness to chemotherapy, the overwhelming majority of advanced ovarian cancer patients relapse with resistant disease. Thus, developing more effective strategies for ovarian cancer treatment is a high clinical priority. Here,...

Increasing access to Science, Technology, Engineering, and Math (STEM) fields can create career opportunities. Yet many students, especially those from lower-income backgrounds, find the high-stakes exams in courses necessary for STEM success to be...

Legionella pneumophila is a bacterial pathogen causing outbreaks of a lethal pneumonia. The genus Legionella comprises 65 species for which aquatic amoebae are the natural reservoirs. Using functional and comparative genomics to deconstruct the...

Noncoding DNA sequences play crucial roles in gene regulation, including via three-dimensional genome organization where they define chromatin boundaries and segment the genome into a sequence of insulated neighborhoods. However, the relative...

Accessions of a plant species can show considerable genetic differences that are analyzed effectively by using recombinant inbred line (RIL) populations. Here we describe the results of genome-wide expression variation analysis in an RIL population...

The ReFRAME collection of 12,000 compounds is a best-in-class drug repurposing library containing nearly all small molecules that have reached clinical development or undergone significant preclinical profiling. The purpose of such a screening...

Arthropods, invertebrates including insects that have external skeletons, are declining at an alarming rate. While the tropics harbor the majority of arthropod species, little is known about trends in their abundance. We compared arthropod biomass...

The misfolding and/or aggregation of proteins can give rise to amyloid diseases, including immunoglobulin light-chain (LC) amyloidosis, leading to large proteinaceous deposits in organs throughout the body. A third of patients die within a year of...

Inequality prospers when successes of advantaged group members (e.g., men, whites) get more attention than equivalent successes of disadvantaged group members (e.g., women, blacks). What determines whose successes individuals deem worth promoting...

An important process in sexual organisms is the shuffling of maternal and paternal DNA in gametes by both crossing over and independent assortment of homologous chromosomes. Traditional measures of the total amount of genetic shuffling simply count...

We cannot assume that the statistics of mass human crises will capture our attention or move us to take action, no matter how large the numbers. The data that we present show that the world was basically asleep as the body count in the Syrian war...

Virtually the first thing a young population genetics student will learn is that changes in gene frequency can be caused by genetic drift, natural selection, and migration. However, quantifying the relative importance of these mechanisms on changes...

Facial masculinity has been considered a sexual ornament in humans, akin to peacock trains and stag antlers. Recently, studies have questioned the once-popular view that facial masculinity is a condition-dependent male ornament signaling...

Many groups of flowering plants have become parasites and have lost the capacity to carry out photosynthesis. The plastid genomes of these parasitic plants are often highly reduced in size and gene content and are divergent in other ways too. Here...

The response of different economic sectors and energy infrastructure to climate warming is complex and difficult to compare with land and ocean carbon cycle feedbacks. Our analysis provides a framework for assessing such economic responses and...