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The proto-oncogene KRAS , a small GTPase, is frequently mutated in pancreatic, colorectal, and lung cancer. These mutations result in elevated levels of the activated guanosine triphosphate-bound form of KRAS. Localized at the plasma membrane, KRAS...

Using the 2016 American National Election Study, we develop comprehensive measures of the current populist moment in the United States. Our purpose is to develop a behavioral analysis of this current socially volatile moment. Using hierarchical...

Alongside climate change, the current rapid loss of biodiversity is one of the biggest threats that humanity faces to its own survival (1). With up to a million species at risk of disappearing within decades, human activities are reshaping life on...

A full picture of the COVID-19 pandemic requires information on how its impact on lives and on livelihoods relates across different groups. We therefore estimate excess all-cause mortality and employment displacement in April 2020 nationally and...

Donald Trump's 2016 victory in the Electoral College without leading in the popular vote has led to speculation of a repeat in 2020. If the Democrats were to win the popular vote but by less than a landslide, could they be thwarted from stopping...

During the Eocene, high-latitude regions were much warmer than today and substantial polar ice sheets were lacking. Indeed, the initiation of significant polar ice sheets near the end of the Eocene has been closely linked to global cooling. Here, we...

Bats have been shown to dampen several key upstream pathogen and danger-associated molecular patterns, yet much of the downstream signaling is yet unknown. Here, we identify residues in caspase-1 which are critical for enzymatic activity and have...

The deep clouds that make up tropical disturbances, the precursors to more intense tropical cyclones (TCs) (including hurricanes and typhoons), effectively trap infrared radiation emitted by Earth’s surface and lower atmosphere. Our results...

Strategically siting marine protected areas (MPAs) in overfished fisheries can have important conservation and food provisioning benefits. We use distribution data for 1,338 commercially important fisheries stocks around the world to model how MPAs...

Recent large-scale sequencing efforts have enabled the detection of millions of missense variants. Elucidating their functional effect is of crucial importance but challenging. We approach this problem by performing a wide-scale characterization of...

Here, we show how a conservation–health care exchange in rural Borneo preserved globally important forest carbon and simultaneously improved human health and well-being, in a region of historically intense environmental destruction, widespread...

How do we build a perception from incoming sensory information? To accurately perceive the environment, the brain has to integrate information across different sensory modalities and to analyze multiple sensory dimensions within a sensory modality....

Socioeconomic disparities in math proficiency are observable when children enter kindergarten, and these disparities persist through the school years. Research suggests that overall proficiency at kindergarten entry depends upon specific skills that...

Mutations are generally thought to accumulate independently and gradually over many generations. Here, we combined complementary experimental approaches in budding yeast to track the appearance of chromosomal changes resulting in...

The United States witnessed large, persistent measles outbreaks in 2019, nearly losing its elimination status, despite achieving national measles vaccination coverage above the World Health Organization recommendation of 95%. Previous research...