BRAF mutations are frequent events in many different cancer types. Here, the authors highlight how distinct BRAF mutations affect the clonal dynamics and architecture of emergent tumours, with potential implications for therapeutic intervention.
Exemestane plus palbociclib with ovarian function suppression showed clinical benefit
compared with capecitabine in terms of improved progression-free survival in premenopausal
patients with hormone receptor-positive, HER2-negative metastatic breast...
The complexity of the innate immune response to cancer makes interpretation of large data sets challenging. Here, the authors provide an integrated multi-scale map of signalling networks representing the different immune cells and their interactions...
Whole-genome sequencing in triple-negative breast cancer supports the prognostic value of the HRDetect mutational-signature-based algorithm for improving patient stratification in a real-world, population-based clinical diagnostic setting.
Thread by @StoverLab: "This is treatment for : 1) Patient with new metastatic disease. Evidence-based treatment recommended. 2) All documentad and submitted with with published evidence as part of Prior authorization. Aggregate provider time: 35...
A study finds evidence for how to reduce some of it, but also a large blind spot on how to remove the rest.
Daniel Stover, MDThe administrative waste in healthcare costs $billions, gets in the way of timely & effective care, and reduces job satisfaction for providers.
This is a fix we can get behind - Let’s start there.
The Huge Waste in the U.S. Health System
It is difficult to discern the relative contributions of ultraviolet-A (UVA; 320-400nm) and ultraviolet-B (UVB; 280-320nm) radiation to human melanoma development. Here, we compared the tumorigenic consequences of a single UVA or UVB exposure in...
One of the country’s fastest-growing cities has seen a surge in homegrown distilleries that are drawing customers with tasting rooms, restaurants and bottle shops.
Daniel Stover, MD“One of the country’s fastest-growing cities has seen a surge in homegrown distilleries that are drawing customers with tasting rooms, restaurants and bottle shops.” @nytimes #ColumbUS
Some of our favorite spots!
The New Hangout in Columbus? Distilleries
High-grade serous ovarian cancer (HGSOC) is often sensitive to initial treatment with platinum and taxane combination chemotherapy, but most patients relapse with chemotherapy-resistant disease. To systematically identify genes modulating...
Integrating different types of data, including electronic health records, imaging data, administrative and claims databases, large data repositories, the Internet of Things, genomics, and other omics data, is both a challenge and an opportunity that...
Nancy Brown, MD, Hugh J. Morgan Professor and chair of the Department of Medicine in the Vanderbilt University School of Medicine, has been named dean of the Yale School of Medicine. She will join Yale on Feb. 1, 2020.
Daniel Stover, MDHad the honor of serving as Dr. Brown’s Chief Resident in her 1st year as Chair of Medicine @VUMChealth
She is a remarkable intellect, a thoughtful leader, & a dedicated mentor.
@YaleMed made a good choice for their next (1st female) Dean!
A Nature analysis finds that several fields of science are moving away from male-dominated conferences and panels — but it’s easy to slip back into old habits.
Daniel Stover, MDWith important moves away from 'manels' and 'manfrences' (see @nature commentary below), I reviewed our speaker list for our monthly @OSUCCC_James Breast Cancer Research Conference and the results are in:
All great speakers