Doctor researching autoimmune causes of psychiatric illness. Psychiatry. Neurology. Immunology. South Asia. Food. Sorry, I can't give medical advice online.
In this interview with Dr Aftab, Dr Nielsen discusses his approach to psychiatry which sees mental disorders as dysfunctions in the behavioral and experiential processes representing “sticky tendencies” in the human brain-body-environment system.
In this interview with Dr Aftab, Dr de Haan discusses her enactive approach to psychiatry which applies insights from enactivism to help conceptualize and navigate the immense complexity of factors that contribute to psychiatric disorders, and...
There are more than 200 subtypes of dementia. And researchers have found that in one, confusion and memory loss can be treated. But the trick is to spot it…
IRAK4 deficiency is an inborn error of immunity predisposing patients to invasive pyogenic infections. Currently, there is no established simple assay that enables precise characterization of IRAK4 mutant alleles in isolation....
Case studies have revealed neurological problems in severely affected COVID-19 patients. However, there is little information regarding the nature and broader prevalence of cognitive problems post-infection or across the full spread of severity. We...
### What you need to know
Functional disorders are conditions whose origin arises primarily from a disorder of nervous system functioning rather than clearly identifiable pathophysiological disease—such as irritable bowel syndrome, fibromyalgia,...
Involvement of oxidative stress in the pathophysiology of schizophrenia (SZ) is suggested by studies of peripheral tissue. Nonetheless, it is unclear how such biological changes are linked to relevant, pathological neurochemistry, and brain...
Objective: To discuss challenges with the diagnosis of autoimmune psychosis (AP) in people with chronic psychotic disorders. Method: We present a case of a 23-y...
Tom PollakReally interesting case study of an apparently false positive NMDAR ab result in CSF - of a patient with chronic (5 yrs) psychosis, serum abs and equivocal EEG. Not sure I can think of many cases where a CSF NMDAR ab was felt not to be pathogenic...
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Catatonia is a severe psychomotor syndrome that frequently occurs in patients with schizophrenia spectrum disorders (SSD). Accumulating neuroimaging evidence suggests orbitofrontal, frontoparietal and cerebellar network dysfunction in catatonia....
Cancer-related cognitive impairment is an important complication in cancer patients,
yet the underlying mechanisms remain unknown. Over the last decade, the field of paraneoplastic
neurological syndromes has been dramatically changed by the...
Tom PollakNeuronal antibody status fluctuated over time, w some subjects developing new abs and some 'losing' theirs. This has been observed by Hannelore Ehrenreich's group and is discussed in an accompanying editorial on our paper by Ehrenreich and @SteixnerAgnes
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Serum neuronal autoantibodies, such as those to the NMDA receptor (NMDAR), are detectable in a subgroup of patients with psychotic disorders. It is not known if they are present before the onset of psychosis or whether they are associated with...
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Tom PollakJUST PUBLISHED! Our new paper in Molecular Psychiatry. Using multiple assays we searched for serum antibodies to neuronal antigens in young people at clinical high risk for psychosis and asked whether they had any clinical or prognostic significance.
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One hundred years ago, neurologists were faced with a surge of cases of uncertain cause manifesting a protean array of symptoms. Through careful semiological description, pattern recognition and histopathological analysis, von Economo and others...
Delirium is a common neurocognitive disorder in hospital settings, characterised by fluctuating impairments in attention and arousal following an acut…