Daniel Himmelstein

PhD Candidate   University of California, San Francisco   Biological & Medical Informatics
Digital craftsman of the biodata revolution and pioneer of data integration for human health.


86 Rephetio: Repurposing drugs on a hetnet
Report published
Welcome to project Rephetio. We aim to predict the probability that a given approved small molecule will treat a given complex disease. First, we construct a hetnet for drug repurposing. The network integrates 29 public resources and contains 47 thousand nodes (of 11 types) and 2.3 million edges ...

Discussion participating

Report Review: Rephetio: Repurposing drugs on a hetnet
[rephetio] 1 day ago
Tracking project reuse, citation, and publicity
[rephetio] 13 days ago
Our hetnet edge prediction methodology: the modeling framework for Project Rephetio
[rephetio] 17 days ago
Why we predicted ictogenic tricyclic compounds treat epilepsy?
[rephetio] 20 days ago
Measuring user contribution and content creation
[rephetio] 50 days ago
One network to rule them all
[rephetio] 53 days ago
Integrating resources with disparate licensing into an open network
[rephetio] 55 days ago
Visualizing the top epilepsy predictions in Cytoscape
[rephetio] 58 days ago
Using Entrez Gene as our gene vocabulary
[rephetio] 62 days ago
Brainstorming future directions for Hetionet
[rephetio] 70 days ago
View all 135 discussions


Comments Title Year
0 Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis 2016
0 Genetic Association–Guided Analysis of Gene Networks for the Study of Complex Traits 2016
0 Meta-analysis of genome-wide association studies reveals genetic overlap between Hodgkin lymphoma and multiple sclerosis 2016
0 Qualifying Exam proposal: Drug repurposing on a heterogeneous network of pathogenesis 2016
0 iCTNet2: integrating heterogeneous biological interactions to understand complex traits 2015
0 iCTNet2: integrating heterogeneous biological interactions to understand complex traits 2015
0 Heterogeneous Network Edge Prediction: A Data Integration Approach to Prioritize Disease-Associated Genes 2015
0 Understanding multicellular function and disease with human tissue-specific networks 2015
0 Lung cancer incidence decreases with elevation: evidence for oxygen as an inhaled carcinogen 2015
0 Evolving hard problems: Generating human genetics datasets with a complex etiology 2011
View all 14 publications

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Impact points2186
Est. earnings$454
Comments rated200


Heterogeneous NetworksMachine learningBiostatisticsBiomedical InformaticsGenomicsNetworksBioinformaticsAlgorithmsComputer ScienceStatisticsNetwork BiologyTerminologiesComputational Biology