The human airway epithelium is the initial site of SARS-CoV-2 infection. We used flow cytometry and single cell RNA-Sequencing to understand how the heterogeneity of this diverse cell population contributes to elements of viral tropism and...
The problem is painful and obvious: while epic sums are being spent, every day more people are dying, and we are all living with fewer freedoms. We would not choose to begin the design of our weapons...
Asadi Shahmirzadi et al. report that an alpha-ketoglutarate-supplemented diet extends
lifespan of middle-aged female mice and increases healthspan in both sexes. With simultaneous
reduction in frailty and increase in longevity, the intervention...
Benjamin tenOeverFirst in worms, then flies, and now mice! Alpha-Ketoglutarate, (AKG) is found to improve aging and extend life.
Harvey J. Alter, Michael Houghton and Charles M. Rice were jointly honored for their “decisive contribution to the fight against blood-borne hepatitis, a major global health problem.”
Benjamin tenOeverSo great to read that the Nobel prize in Medicine has been awarded to three virologists. I feel society has not given enough attention to the fact that the community discovered than cured HCV. Congratulations to all three!
The COVID-19 vaccines furthest along in clinical trials are the fastest to make, but they are also the hardest to deploy.
Benjamin tenOeverAn interesting difference between the Moderna and Pfizer mRNA vaccines. Moderna RNA is more stable at temperatures of +4 to -20 degrees Celsius whereas the Pfizer vaccine needs to be maintained at -80 which will significantly limit distribution.
The world is in the midst of an ongoing pandemic caused by the novel and highly contagious SARS-CoV-2. There is marked inter-individual variability in the tissues affected as well as the severity of response to SARS-CoV-2. It is unclear why some...
Advisory groups around the world release guidance to prioritize healthcare workers and others.
Benjamin tenOeverThe National Academy of Sciences has a draft plan for #COV2 vaccine distribution post #FDA approval. First, health care workers and 1st responders. Second, ppl with co-morbidities. Third, essential workers. Fourth, the youth. Fifth, everyone else.
Background and aims: Immune dysregulation caused by SARS-CoV-2 infection is thought to play a pathogenic role in COVID-19. SARS-CoV-2 can infect a variety of host cells, including intestinal epithelial cells. We sought to characterize the role of...
Entry of SARS-CoV-2 is facilitated by endogenous and exogenous proteases. These proteases proteolytically activate the SARS-CoV-2 spike glycoprotein and are key modulators of virus tropism. We show that SARS-CoV-2 naïve serum exhibits significant...
The rising threat of pandemic viruses, such as SARS-CoV-2, requires development of new preclinical discovery platforms that can more rapidly identify therapeutics that are active in vitro and also translate in vivo. Here we show that human...
Benjamin tenOeverCan amodiaquine (AQ) short circuit this pandemic? It is an FDA-approved, orally available pill. We still need to test in humans but check out Fig5 in our preprint. AQ cuts viral loads and reduces transmission by many orders of magnitude in vivo.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 20191,2 and is responsible for the COVID-19 pandemic3. Vaccines are an essential countermeasure urgently needed to control the pandemic4. Here, we show that the...
Around the tenth day after diagnosis, ∼20% of patients with coronavirus disease 2019 (COVID-19)−associated pneumonia evolve toward severe oxygen dependence (stage 2b) and acute respiratory distress syndrome (stage 3) associated with systemic...
Benjamin tenOeverThe power of immune modulation. Similar to treating Cytokine Release Syndrome, blocking IL1 (and IL6) shows therapeutic value for treating #COVID19
In this manuscript, the authors address evolutionary questions on the emergence of SARS-CoV-2. They find that SARS-CoV-2 is not a recombinant of any sarbecoviruses detected to date, and that the bat and pangolin sequences most closely related to...
This study compares angiotensin-converting enzyme 2 (ACE2) gene expression, which has been associated with SARS-CoV-2 cell entry, in the nasal epithelium of children vs adults.
Benjamin tenOeverAre the levels of #ACE2 significantly lower in kids under 10? Might this explain why they're generally asymptomatic for #SARSCoV2? There is data to support this claim but I would love to be informed of other results on the topic ja.ma/3eZG7Uk@macroliter@SCOTTeHENSLEY
This case series describes rare putative X-chromosomal loss-of-function variants associated with impaired peripheral mononuclear blood cell interferon signaling in 4 young male patients hospitalized with severe coronavirus disease 2019 (COVID-19) in...
Benjamin tenOeverYoung people with severe #COVID19 show mutation in TLR7. Suggests uninfected cells such as pDCs that scavenge for viral RNA are key to controlling the virus. Does advanced age decrease IFN-I biology as well? JAMA Network